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tag rna polymerase ecology cell molecular biology

DNA molecule.
Finding DNA Tags in AAV Stacks
Mariella Bodemeier Loayza Careaga, PhD | Mar 7, 2024 | 8 min read
Ten years ago, scientists put DNA barcodes in AAV vectors, creating an approach that simplified, expedited, and streamlined AAV screening. 
Microfluidics: Biology’s Liquid Revolution
Laura Tran, PhD | Feb 26, 2024 | 8 min read
Microfluidic systems redefined biology by providing platforms that handle small fluid volumes, catalyzing advancements in cellular and molecular studies.
Polymerase Pieces
Jef Akst | Dec 1, 2014 | 2 min read
Researchers discover a new subunit of a bacterial RNA polymerase—as well as hints of its potential role in defending against viruses.
Molecular Biology
The Scientist Staff | Dec 9, 1990 | 1 min read
S. Hahn, S. Buratowski, P.A. Sharp, L. Guarente, "Isolation of the gene encoding the yeast TATA binding protein TFIID: a gene identical to the SPT15 suppressor of Ty element insertions," Cell, 58, 1173-81, 22 September 1989. Steven Hahn (Fred Hutchinson Cancer Research Center, Seattle): "TFIID is one of the essential components in the machinery necessary to initiate transcription by RNA polymerase II. For eight years after the discovery of TFIID in mammals, little was known about it because of
Black and gold sketch of Katalin Karikó and Drew Weissman.
Nobel Prize for mRNA Vaccines
Danielle Gerhard, PhD | Oct 2, 2023 | 5 min read
Katalin Karikó and Drew Weissman received this year’s Physiology or Medicine award for their work on RNA biology and mRNA-based vaccines.
Molecular Biology
The Scientist Staff | Mar 29, 1992 | 1 min read
C. Jonat, H.J. Rahmsdorf, K.-K. Park, A.C.B. Cato, S. Gebel, H. Ponta, P. Herrlich, "Antitumor promotion and antiinflammation: down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone," Cell, 62:1189-1204, 1990. Helmut Ponta (Kernforschungs-zentrum Karlsruhe, Germany): "Our paper was the first in a series that show that members of the steroid receptor family and the transcription factor AP-1 (Fos/Jun) mutually interfere with each other without change in DNA occupancy. Thus, bona fi
A person moving the hands of a vintage clock backwards.
Synthetic Circuits Reveal the Key to Rewinding the Cellular Clock
Charlene Lancaster, PhD | Mar 12, 2024 | 4 min read
Using a circuit-based system, scientists determined the ideal transcription factor levels to promote the successful reprogramming of fibroblasts into induced pluripotent stem cells.
Eytan Stibbe wears a headset and a blue shirt while surrounded by computers and other equipment on the International Space Station.
Whenever, Wherever: Taking DNA Amplification Outside the Lab
Hannah Thomasy, PhD | Dec 4, 2023 | 10 min read
Recombinase polymerase amplification lets researchers rapidly replicate DNA in the clinic, in the field, or even in the International Space Station.
Molecular Biology
The Scientist Staff | Dec 9, 1990 | 1 min read
M.C. Schmidt, C.C. Kao, R. Pei, A.J. Berk, "Yeast TATA-box transcription factor gene," Proceedings of the National Academy of Sciences, 86, 7785-9, October 1989. Arnold Berk (University of California, Los Angeles): "TFIID binding to a TATA box initiates the ordered assembly of multiple transcription factors (TFs) required for initiation on eukaryotic promoters. However, TFIID resisted purification from higher organisms, preventing detailed studies of the process. We were interested in TFIID be
Different colored cartoon viruses entering holes in a cartoon of a human brain.
A Journey Into the Brain
Danielle Gerhard, PhD | Mar 22, 2024 | 10+ min read
With the help of directed evolution, scientists inch closer to developing viral vectors that can cross the human blood-brain barrier to deliver gene therapy.

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