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tag alzheimer s disease disease medicine ecology culture immunology

What Causes Alzheimer’s?
W. Sue T. Griffin | Sep 1, 2011 | 10 min read
Researchers and pharma companies have tried to attack this disease by reducing amyloid plaques, but inflammation may be the real culprit.
bacteria and DNA molecules on a purple background.
Engineering the Microbiome: CRISPR Leads the Way
Mariella Bodemeier Loayza Careaga, PhD | Mar 15, 2024 | 10+ min read
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.
Rendering of a light blue NLRP3 inflammasome against a black background
Inflammation in Brain’s Immune Cells Triggers Depressive Behavior in Mice
Dan Robitzski | Nov 17, 2022 | 5 min read
In stressful conditions, specialized protein complexes in microglia induce neurotoxic activity in astrocytes that leads to the change in behavior.
a false color transmission electron microscope image of a neuronal cell body, with lysosomes colored dark green
Scientists Uncover Major Pathway Cells Use to Mend Leaky Lysosomes
Holly Barker, PhD | Oct 6, 2022 | 3 min read
Damaged lysosomes are repaired by a lipid-based signaling pathway dubbed PITT that could be targeted to treat neurodegenerative disease, its discoverers say.
Alzheimer Research Joins the Mainstream
Christine Bahls | Jan 20, 2002 | 5 min read
In 1977, Alzheimer Disease researcher Peter Davies spoke with some neurologists about his work, which he began a year earlier. "One [neurologist] said, 'This is lovely..., but why don't you work on something that is more common?'" he remembers. Davies says the comment epitomized scientists' then-dismissive attitude about Alzheimer Disease (AD). When Alois Alzheimer first identified this memory-destroying disorder in 1907, his patient was a 50-year-old woman; a very early age, as researchers now
Top People of 2011
Jef Akst | Dec 21, 2011 | 6 min read
The Scientist recounts the year’s top science prize winners and top-notch scientists that passed away.
Week in Review: May 23–27
Tracy Vence | May 27, 2016 | 2 min read
Potential link between microbial infection and Alzheimer’s disease; CRISPR-enabled cell lineage tracing; image irregularities lead to anticipated retraction; brain glucose metabolism and consciousness; exploring emotional contagion; Zika-related microcephaly risk estimated
Frontlines
Hal Cohen | Feb 17, 2002 | 5 min read
New evidence points to brain trauma as an environmental risk factor for Alzheimer disease (AD). 
Brain cell in purple on a black background. Arc mRNAs are labeled green and are mainly localized in the cell nucleus and in the dendrites.
Short-lived Molecules Support Long-term Memory 
Alejandra Manjarrez, PhD | Jun 6, 2023 | 3 min read
A gene essential for information storage in the brain engages an autoregulatory feedback loop to consolidate memory.
2020 Top 10 Innovations
The Scientist | Dec 1, 2020 | 10+ min read
From a rapid molecular test for COVID-19 to tools that can characterize the antibodies produced in the plasma of patients recovering from the disease, this year’s winners reflect the research community’s shared focus in a challenging year.

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