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tag lyme disease microbiology genetics genomics

bacteria and DNA molecules on a purple background.
Engineering the Microbiome: CRISPR Leads the Way
Mariella Bodemeier Loayza Careaga, PhD | Mar 15, 2024 | 10+ min read
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.
Haydeh Payami is wearing a purple dress and an orange and pink scarf and standing in front of a whiteboard.
A Microbial Link to Parkinson’s Disease
Mariella Bodemeier Loayza Careaga, PhD | Dec 4, 2023 | 6 min read
Haydeh Payami helped uncover the genetic basis of Parkinson’s disease. Now, she hopes to find new ways to treat the disease by studying the gut microbiome.
The Search for Persisters
Amanda B. Keener | Aug 11, 2015 | 4 min read
Lyme disease–causing bacteria can outmaneuver antibiotics in vitro and manipulate the mouse immune system.
Researchers in George Church&rsquo;s lab modified wild type ADK proteins (left) in <em >E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.
A Pioneer of The Multiplex Frontier
Rashmi Shivni, Drug Discovery News | May 20, 2023 | 10 min read
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.
Researchers Blast Open Pathogen Genome
Barry Palevitz | Aug 18, 2002 | 6 min read
Image: Courtesy of Tim Elkins BRUTE FORCE: Remnant of an appressorium formed on Mylar. The appressorium produced a peg-like extension that penetrated the film, leaving a round hole. (Reprinted with permission, Annual Review of Microbiology, 50:491-512, 1996.) "The Lord shall smite thee with a consumption, and with a fever, and with an inflammation, and with an extreme burning, and with the sword, and with BLASTING, and with mildew; and they shall pursue thee until thou perish." Deuteronom
An illustration of green bacteria floating above neutral-colored intestinal villi
The Inside Guide: The Gut Microbiome’s Role in Host Evolution
Catherine Offord | Jul 1, 2021 | 10+ min read
Bacteria that live in the digestive tracts of animals may influence the adaptive trajectories of their hosts.
Top 7 in Immunology
Edyta Zielinska | Aug 2, 2011 | 3 min read
A snapshot of the most highly ranked articles in microbiology and related areas, from Faculty of 1000
Epigenetics: Genome, Meet Your Environment
Leslie Pray | Jul 4, 2004 | 10+ min read
©Mehau Kulyk/Photo Researchers, IncToward the end of World War II, a German-imposed food embargo in western Holland – a densely populated area already suffering from scarce food supplies, ruined agricultural lands, and the onset of an unusually harsh winter – led to the death by starvation of some 30,000 people. Detailed birth records collected during that so-called Dutch Hunger Winter have provided scientists with useful data for analyzing the long-term health effects of prenat
Software Helps Researchers In Sorting Through The Human Genome
Ricki Lewis | Jul 21, 1996 | 10 min read
The Human Genome SIDEBAR : Selected Suppliers of Software for Gene Discovery and Analysis Genetics has been an informational science since the elucidation of DNA's structure. Today's researchers say the field shifted to a more computational mode in 1990-the year that research groups began mapping genes to specific chromosomal sites for the Human Genome Project. "That year was pivotal, because it was then that the need to sequence significant amounts of DNA became compelling," says Richard Gib
Comparative Genomics Reveals The Interrelatedness Of Life
Ricki Lewis | Jan 4, 1998 | 7 min read
Photo: Karen Young Kreeger EXCITING ERA: TIGR's Craig Venter says efforts to unravel the information being gathered will last "into the next century." While the list of genome projects grows, research focus is shifting from structure to function. So even as automated DNA sequencers crank out bases and powerful software overlaps pieces of genomes (contigs) to establish gene orders, investigators are searching and comparing those sequences among species, an approach called comparative genomics.

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