vaccine, immunology, disease & medicine

Rollouts of the shot have ground to a halt following reports of blood clots, but health authorities say that these fears are unfounded and vaccination programs should continue.

Mix-and-match shots could simplify vaccine rollout and stimulate more-robust immune responses. Ongoing clinical trials will soon give answers.

The P.1 variant, which has also been detected in five US states, could be responsible for cases of reinfection, according to a preprint.

Researchers identify deletions in the N-terminal domain of the spike protein that allow the coronavirus to avoid antibody neutralization and that may contribute to the emergence of new variants.

New data suggest that the company’s approved COVID-19 vaccine protects against different virus variants, but could be less effective against the one that originated in South Africa.

An additional mutation in the spike protein of the coronavirus may help it elude antibody recognition, and scientists are investigating if current vaccines will protect against it.

Half a year after infection, people who had recovered from COVID-19 had robust antibodies, along with traces of the virus in their gut, which may drive long-lasting immunity.

Outcomes in COVID-19 patients may be better in those recently infected with endemic coronaviruses. 

A recent study elucidates some of the changes that occur in the body after inoculation with a tuberculosis vaccine.

Repeat COVID-19 cases could offer clues about people’s immunity to the novel coronavirus and how to vaccinate against it.

The company voluntarily paused its studies, including one in Phase 3, after an unexplained illness in a patient.

Adenovirus vectors deliver the genetic instructions for SARS-CoV-2 antigens directly into patients’ cells, provoking a robust immune response. But will pre-existing immunity from common colds take them down?

A study of Nicaraguan children links prior Zika virus infection with aggravated dengue fever symptoms.

A clinical trial of the shot in eight volunteers suggests that it is safe and that it generates antibodies that neutralize SARS-CoV-2, but further testing is needed, scientists say.

While the finding doesn’t prove people become immune to the virus after infection, it is good news for vaccine development.

Studies are underway to test whether giving a shot of BCG vaccine could protect doctors and nurses against COVID-19.

The 2019 Lasker medical and research awards celebrate advances in scientists’ understanding of T and B cells, Herceptin antibodies for treating breast cancer, and vaccine coverage around the globe.

Numerous experimental vaccines that aim to provide multi-season protection are in human studies.

The receptors, found in so-called elite controllers who don’t need medications to keep the virus in check, suggest a new path toward immunotherapy.