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image: Infographic: Proteasome Basics

Infographic: Proteasome Basics

By John Hines and Craig M. Crews | May 1, 2017

The structure and function of the cell's protein-degrading machine

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image: Biochemistry Pioneer Dies

Biochemistry Pioneer Dies

By Tracy Vence | June 3, 2015

Irwin “Ernie” Rose, who shared the 2004 Nobel Prize in Chemistry for his work on ubiquitin-mediated protein degradation, has passed away at age 88.

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image: Cellular Garbage Disposal Illuminated

Cellular Garbage Disposal Illuminated

By Bob Grant | April 13, 2015

A Harvard team shows how cells label and recognize proteins for degradation.

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image: Neil Bence: Manipulating Degradation

Neil Bence: Manipulating Degradation

By Kerry Grens | December 1, 2012

Senior Scientist, Millennium Pharmaceuticals: The Takeda Oncology Company Age: 39

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image: Ubiquitin Chains in Action

Ubiquitin Chains in Action

By Keith D. Wilkinson and David Fushman | July 1, 2012

Present in every tissue of the body, ubiquitin appears to be involved in a dizzying array of functions, from cell cycle and division to organelle and ribosome biogenesis, as well as the response to viral infection. The protein plays at least two role

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Daniel Durocher: Change is Good

By Kerry Grens | July 1, 2012

Senior Investigator, Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada. Age 40

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image: On the Chain Gang

On the Chain Gang

By Keith D. Wilkinson and David Fushman | July 1, 2012

More than simply helping haul out a cell’s garbage, ubiquitin, with its panoply of chain lengths and shapes, marks and regulates many unrelated cellular processes.

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image: Ubiquitin basics

Ubiquitin basics

By Keith D. Wilkinson and David Fushman | July 1, 2012

Despite its discovery as a protein that seems to show up everywhere, at least in eukaryotic cells, researchers are only beginning to scratch the surface of all of the cellular functions involving ubiquitin. 

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image: Forced Feeding

Forced Feeding

By Edyta Zielinska | February 1, 2012

Editor's choice in drug development

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image: Come Inside

Come Inside

By Richard P. Grant | March 1, 2011

Editor's choice in immunology

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