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tag gene therapy cell molecular biology evolution genetics genomics developmental biology microbiology

DNA molecule.
Finding DNA Tags in AAV Stacks
Mariella Bodemeier Loayza Careaga, PhD | Mar 7, 2024 | 8 min read
Ten years ago, scientists put DNA barcodes in AAV vectors, creating an approach that simplified, expedited, and streamlined AAV screening. 
Infusion of Artificial Intelligence in Biology
Meenakshi Prabhune, PhD | Feb 23, 2024 | 10 min read
With deep learning methods revolutionizing life sciences, researchers bet on de novo proteins and cell mapping models to deliver customized precision medicines.
Green and red fluorescent proteins in a zebrafish outline the animal’s vasculature in red and lymphatic system in green in a fluorescent image. Where the two overlap along the bottom of the animal is yellow.
Serendipity, Happenstance, and Luck: The Making of a Molecular Tool
Shelby Bradford, PhD | Dec 4, 2023 | 10+ min read
The common fluorescent marker GFP traveled a long road to take its popular place in molecular biology today.
Different colored cartoon viruses entering holes in a cartoon of a human brain.
A Journey Into the Brain
Danielle Gerhard, PhD | Mar 22, 2024 | 10+ min read
With the help of directed evolution, scientists inch closer to developing viral vectors that can cross the human blood-brain barrier to deliver gene therapy.
Bugs as Drugs to Boost Cancer Therapy
Danielle Gerhard, PhD | Jan 18, 2024 | 7 min read
Bioengineered bacteria sneak past solid tumor defenses to guide CAR T cells’ attacks.
Gene Splicing Pioneer Dale Kaiser Dies
Ashley Yeager | Jun 29, 2020 | 5 min read
Working with a virus that infects bacteria, the Stanford University biochemist and developmental biologist helped to develop a way to stitch DNA together, a discovery that gave rise to genetic engineering.
bacteria and DNA molecules on a purple background.
Engineering the Microbiome: CRISPR Leads the Way
Mariella Bodemeier Loayza Careaga, PhD | Mar 15, 2024 | 10+ min read
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.
Gene Therapy
The Scientist Staff | Aug 30, 1998 | 3 min read
Inder Verma L. Naldini, U. Blomer, P. Gallay, D. Ory, R. Mulligan, F.H. Gage, I.M. Verma, D. Trono, "In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector," Science, 272:263-7, 1996. (Cited in more than 185 papers since publication) Comments by Inder M. Verma, American Cancer Society professor of molecular biology at the Salk Institute for Biological Studies, La Jolla, Calif. In the world of gene therapy, there's a fine line between friend and foe. HIV at
Whither Cell Biology?
Richard Hynes | Dec 10, 2000 | 6 min read
Illustration: A. Canamucio Cell biology has become the third overlapping core discipline of modern biology, along with biochemistry and genetics. Progress over the century--since E.B. Wilson's classic book1 elegantly framed many of the questions of cell biology--has relied on advances in technology and yielded fascinating insights into the ways that cells work. We now have an unprecedented understanding of the structure, organization, and functions of cells. As the number of completed ge
The giant virus <em >Pandoravirus neocaledonia&nbsp;</em>inside the amoeba <em>Acanthamoeba castellanii</em>.
Giant Viruses Grew Out of Small Ones: Study
Kamal Nahas, PhD | Feb 13, 2023 | 4 min read
A study employing CRISPR/Cas9 to explore the evolutionary beginnings of some giant viruses finds evidence their large genomes arose from gene duplications.

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