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tag chaperone mediated autophagy evolution disease medicine neuroscience cell molecular biology

Eat Yourself to Live: Autophagy’s Role in Health and Disease
Vikramjit Lahiri and Daniel J. Klionsky | Mar 1, 2018 | 10+ min read
New details of the molecular process by which our cells consume themselves point to therapeutic potential.
Different colored cartoon viruses entering holes in a cartoon of a human brain.
A Journey Into the Brain
Danielle Gerhard, PhD | Mar 22, 2024 | 10+ min read
With the help of directed evolution, scientists inch closer to developing viral vectors that can cross the human blood-brain barrier to deliver gene therapy.
Waste-Management Consultant
Megan Scudellari | Nov 1, 2013 | 9 min read
By audaciously pursuing an abandoned area of research, Ana María Cuervo discovered how cells selectively break down their waste, and revealed the health consequences when that process malfunctions.
Researchers in George Church&rsquo;s lab modified wild type ADK proteins (left) in <em >E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.
A Pioneer of The Multiplex Frontier
Rashmi Shivni, Drug Discovery News | May 20, 2023 | 10 min read
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.
Image of someone scratching their skin.
A Chronic Itch: Burrowing Beneath the Skin
Brian S. Kim, MD | Sep 8, 2023 | 9 min read
We have barely scratched the surface of itch science and what it indicates about our health.
The Genes of Parkinson’s Disease
Bobby Thomas and M. Flint Beal | Feb 1, 2011 | 10 min read
The minority of Parkinson’s cases now known to have genetic origins are shedding light on the cellular mechanisms of all the rest, bringing researchers closer to a cause—and perhaps a cure.
Longevity
Jill Adams(juadams@the-scientist.com) | May 8, 2005 | 7 min read
During autophagy-literally "self-eating"-cells deliver cytoplasmic constituents, including whole organelles, to the lysosome for degradation.
New Molecular Tools Revealing Mysteries Of The Mind
Karen Young Kreeger | Feb 2, 1997 | 10 min read
Sidebar: Society for Neuroscience NEW MESSENGERS: Caltech’s Erin Schuman and colleagues discovered that one form of nitric oxide is important to long-term potentiation. Can you recall where you were when you heard about the explosion of the space shuttle Challenger? Why is it that, almost universally, people can remember with vivid and instantaneous detail this tragic event when they can't recall what they had for dinner just days before? How are some memories indelibly hard-wired into o
Protein Folding: Theory Meets Disease
Philip Hunter | Sep 7, 2003 | 10+ min read
Protein folding raises some of biology's greatest theoretical challenges. It also lies at the root of many diseases. For example, the fundamental question of whether a protein's final tertiary conformation, sometimes called the native state, can be predicted from its primary amino acid sequence is also of vital importance in understanding the protein's potential capacity to form disease-inducing aggregates. MISS A FOLD, PROMPT A DISEASE Here's a list of protein folding-related disease catego
The Genes of Parkinsons Disease
Bobby Thomas and M. Flint Beal | Feb 1, 2011 | 7 min read
By Bobby Thomas and M. Flint Beal The Genes of Parkinson’s Disease The minority of Parkinson’s cases now known to have genetic origins are shedding light on the cellular mechanisms of all the rest, bringing researchers closer to a cause—and perhaps a cure. Gerald Slota It took centuries for the slumped posture, trembling hands, poor balance, and cognitive impairments that characterize Parkinson’s disease (PD) to be recognized as manifest

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