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tag proteasome developmental biology

When the Lights Went On for COP
Eugene Russo | Feb 15, 2004 | 5 min read
EYE CANDY:Courtesy of Greg Suh, University of California Los Angeles, Andrew Moore, InfrancoMoore GroupThis developing eye from a chimeric Drosophila has wild-type tissue at the top and csn5 mutant tissue at the bottom causing disorganization. Overlaid is a schematic showing the predicted metalloprotease site of CSN5 cleaving an isopeptide bond.It doesn't take a green thumb to predict what happens to plants left in the dark: They wither. But in the late 1980s and early 1990s, researchers, includ
The Shape of Heredity
Susan M. Gasser | Jul 1, 2009 | 10+ min read
By Susan M. Gasser The Shape of Heredity Tracking the dance of DNA and structural proteins within the nucleus shows that placement makes the difference between gene activity and silence. What's true of the best architecture is also true of cellular structures: form follows function. We biologists often take this mantra to an extreme, searching for the function of a molecule or gene without much consideration of its structure, its phys

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