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tag phosphatidylinositol pi 3 kinase cell molecular biology genetics genomics

Top 7 in Molecular Biology
Cristina Luiggi | Aug 16, 2011 | 3 min read
A snapshot of the most highly ranked articles in molecular biology, from Faculty of 1000
Tagged for Cleansing
Michele Pagano | Jun 1, 2009 | 10+ min read
Tagged for Cleansing Not just the cell's trash and recycling center, the ubiquitin system controls complex cellular pathways with elegant simplicity and precision. By Michele Pagano have always gravitated toward order. I may even take it a bit too far according to friends who liken my office to a museum. However, I like to think it not a compulsion, but a Feng Shui approach to life. With this need for order, I may have been better suited to
Top 7 in Genomics & Genetics
Bob Grant | Jul 19, 2011 | 3 min read
A snapshot of the most highly ranked articles in genomics, genetics, and related areas, from Faculty of 1000
A rendering of a human brain in blue on a dark background with blue and white lines surrounding the brain to represent the construction of new connections in the brain.
Defying Dogma: Decentralized Translation in Neurons
Danielle Gerhard, PhD | Sep 8, 2023 | 10+ min read
To understand how memories are formed and maintained, neuroscientists travel far beyond the cell body in search of answers.
Long live the worm!
Jeff Perkel | Jun 29, 2005 | 1 min read
In tomorrow's (July 1) issue of Genes & Development, Siu Sylvia Lee, of the department of molecular biology and genetics at Cornell University in Ithaca, NY, and Gary Ruvkun, of the department of genetics at Harvard Medical School, report ?the first genome-wide functional genomic screen for longevity genes.? The two teams used a library of 16,475 RNA interference constructs (created by Julie Ahringer at the University of Cambridge, UK) to inactivate genes in the nematode, Caenorhabditis eleg
Playing Protein Hide and Seek
Mignon Fogarty | Apr 11, 2004 | 6 min read
LIGHTING THEIR LOCATIONS:© 2002 Cold Spring Harbor PressImmunolocalization of epitope-tagged proteins. (A-E) represent cells containing HAT-tagged proteins stained with the DNA dye, DAPI, and a monoclonal antibody against hemagluttinin, α-HA. At right the images are merged. (F-J) indicates cells carrying V5 tagged proteins. The bar equals 2 μm.Aliens sifting through the remains of a lost human civilization might puzzle over the function of a ladle. But if found in a room associate
Investigating Molecular Motors Step by Step
Jeffrey Perkel | Mar 14, 2004 | 10+ min read
Thom Graves MediaThe audience, several hundred biophysicists strong, was not expecting a James Brown impersonation. But there he was: Physiologist Yale Goldman, keynote speaker on motility at the Biophysical Society's annual meeting, doing his "asymmetric hand-over-hand motility dance with a limp" to tinny strains of "Papa's Got a Brand New Bag." And while Goldman, who eschewed Brown's trademark, over-the-top couture for understated, Ivy League-issue khakis and blue blazer, won't star on MTV any
How Cells Find Their Way
Laura Defrancesco | Sep 2, 2001 | 5 min read
Organisms need to sense their environment. By sensing, they can develop, heal wounds, protect against invaders, and create blood vessels. Chemotaxis, or directional sensing, allows cells to detect chemicals with exquisite sensitivity. Some chemotactic cells can sense chemical gradients that differ by only a few percent from a cell's front to its back. Although discovery of the molecule types involved in chemotaxis, as with other kinds of cell signaling events, has mounted, the details of how thi
Master of the Cell
Judy Lieberman | Apr 1, 2010 | 10+ min read
By Judy Lieberman Master of the Cell RNA interference, with its powerful promise of therapy for many diseases, may also act as a master regulator of most—if not all—cellular processes. RNA silencing. Computer artwork showing a length of RNA (yellow with red rings) bound to an RNA-induced silencing complex (RISC). © Medi-Mation Ltd / Photo Researchers, Inc. ne of the biggest surprises in biology in the past d
Imaging in 4-D
A. J. S. Rayl | Apr 29, 2001 | 10 min read
Just a few short decades ago, cell biologists--essentially relegated to the tissue culture equivalent of Flatland--couldn't imagine working in three dimensions without sacrificing their subjects, much less having the ability to view the impact of their work in real time, over time. Now, state-of-the-art imaging technologies and new biological reagents and probes are sending biologists and other scientists on fantastic voyages into the molecular world of living animals to watch how cancer develop

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