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Single-cell genome analyses reveal the amount of mutations a human brain cell will collect from its fetal beginnings until death.

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image: Opinion: How to Define Cell Type

Opinion: How to Define Cell Type

By Sara B. Linker, Tracy A. Bedrosian, and Fred H. Gage | November 1, 2017

Advances in single-cell technologies have revealed vast differences between cells once thought to be in the same category, calling into question how we define cell type in the first place.

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Genomic analysis of an oak tree that lived during Napoleon’s time supports the idea that plants somehow avoid the accumulation of mutations in their stem cells.

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image: DNA Replication Errors Contribute to Cancer Risk

DNA Replication Errors Contribute to Cancer Risk

By Anna Azvolinsky | March 23, 2017

A follow-up study confirms that random mutations acquired during normal stem cell division likely play a major role in cancer incidence.

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image: Abundant Sequence Errors in Public Databases

Abundant Sequence Errors in Public Databases

By Ruth Williams | February 16, 2017

A new algorithm reveals hoards of preparation-induced DNA mutations in publicly available human sequences.

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image: Smoking-Linked Cancer Mutations Mapped

Smoking-Linked Cancer Mutations Mapped

By Anna Azvolinsky | November 3, 2016

Scientists produce a detailed genomic map of mutations and epigenetic changes associated with smoking tobacco across 17 tumor types. 

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image: Sequencing Reveals Genomic Diversity of the Human Brain

Sequencing Reveals Genomic Diversity of the Human Brain

By Ben Andrew Henry | September 16, 2016

Researchers examine the role of long interspersed element-1 retrotransposition in neuronal mosaicism.

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image: Monitoring Mitochondrial Mutations

Monitoring Mitochondrial Mutations

By Catherine Offord | April 18, 2016

Induced pluripotent stem cells—particularly those generated from older patients—should be screened for defects in mitochondrial DNA, a study shows.

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image: Low Mutation Rate in iPSCs

Low Mutation Rate in iPSCs

By Catherine Offord | April 11, 2016

The mutation rate in induced pluripotent stem cells is 10 times lower than in somatic cells, scientists show.

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image: Mosaic Mutations May Not Be Rare

Mosaic Mutations May Not Be Rare

By Anna Azvolinsky | June 5, 2015

Somatic mosaicism may be responsible for a larger proportion of genomic variability within humans than previously thought.

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