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tag drug development immunology culture ecology microbiology

Bugs as Drugs to Boost Cancer Therapy
Danielle Gerhard, PhD | Jan 18, 2024 | 7 min read
Bioengineered bacteria sneak past solid tumor defenses to guide CAR T cells’ attacks.
bacteria and DNA molecules on a purple background.
Engineering the Microbiome: CRISPR Leads the Way
Mariella Bodemeier Loayza Careaga, PhD | Mar 15, 2024 | 10+ min read
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.
A needle drawing up fluid from an unlabeled vial.
Cancer Vaccination as a Promising New Treatment Against Tumors
Shelby Bradford, PhD | Mar 15, 2024 | 10+ min read
Vaccination has beaten back infections for more than a century. Now, it may be the next big step in battling cancer.
Infographic: Maternal Microbiota Has Lasting Effects on Offspring
Carolyn A. Thomson and Kathy D. McCoy | Aug 1, 2021 | 3 min read
Work in rodents shows that the bacteria living in a mother’s gut can produce immunomodulatory metabolites and influence the production of maternal antibodies—both of which can affect her offspring’s development.
The Role of Mom’s Microbes During Pregnancy
Carolyn A. Thomson and Kathy D. McCoy | Aug 1, 2021 | 10+ min read
Bacteria in the gut influence the production of antibodies and themselves secrete metabolites. In a pregnant woman, these compounds may influence immune development of her fetus.
Bladder epithelial tissue, where cell junctions are shown in green and nuclei in blue. This was grown in vitro from cells taken from mice with chronic cystitis.
Bladder ‘Memory’ Influences Urinary Tract Infection Recurrence in Mice
Alejandra Manjarrez, PhD | Apr 12, 2023 | 3 min read
Urinary tract infections leave permanent epigenetic marks in the mouse bladder epithelium, reprogramming its response to subsequent infections, a study finds.
A section of a mouse distal colon showing luminal contents with bacteria in magenta, the mucus lining (green) and the epithelial cell barrier of the gut (blue, right).
Mapping the Neighborhoods of the Gut Microbiome
Abby Olena, PhD | Jul 1, 2022 | 7 min read
Researchers are going beyond fecal samples to understand how the patterns of commensal microbes in the gastrointestinal tract influence development and health.
Top 7 in Immunology
Edyta Zielinska | Aug 2, 2011 | 3 min read
A snapshot of the most highly ranked articles in microbiology and related areas, from Faculty of 1000
The Vaginal Microbiome is Finally Getting Recognized
Hannah Thomasy, PhD, Drug Discovery News | Sep 25, 2023 | 10+ min read
Vaginal dysbiosis has long been a taboo subject, but studying and optimizing the vaginal microbiome could be a game changer for women's health.
Illustration of viruses represented with different colors overlapping each other.
What Happens When You Catch More than One Virus?
Alejandra Manjarrez, PhD | Dec 7, 2022 | 8 min read
The “tripledemic” shines a spotlight on viral interference, in which one infection can block another.

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