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tag induced pluripotent stem cell neuroscience evolution cell molecular biology developmental biology

A person moving the hands of a vintage clock backwards.
Synthetic Circuits Reveal the Key to Rewinding the Cellular Clock
Charlene Lancaster, PhD | Mar 12, 2024 | 4 min read
Using a circuit-based system, scientists determined the ideal transcription factor levels to promote the successful reprogramming of fibroblasts into induced pluripotent stem cells.
Stem Cell Trial for Eye Disease Commences
Jef Akst | Sep 12, 2014 | 2 min read
Researchers at the RIKEN Center for Developmental Biology will treat the first patient in its clinical trial testing an induced pluripotent stem cell-based treatment for age-related macular degeneration.
Artist’s rendition of a blue-green DNA double helix, viewed lengthwise from within one end.
Stem Cell Lines Riddled With Undetected Mutations
Dan Robitzski | Aug 12, 2022 | 4 min read
Most of the human induced pluripotent stem cells stored at major cell line repositories and used in research harbor thousands of DNA errors, a study finds, highlighting the need for improved quality control measures.
Top 7 in developmental biology
Bob Grant | Dec 17, 2010 | 3 min read
A snapshot of the most highly ranked articles in developmental biology, from Faculty of 1000
Use of Induced Pluripotent Stem Cells in Drug Discovery: Challenges and Opportunities
The Scientist Marketing Team | Sep 26, 2013 | 3 min read
The Scientist brings together a panel of experts who parse the hope and hype in an effort to educate the audience about the successes and caveats of using iPSCs.
This is an image of a bioluminescent from gene expression reporter in stem cells from a rhinoceros.
A Stem Cell Zoo Reveals Surprising Differences in Embryogenesis
Ida Emilie Steinmark, PhD | Sep 1, 2023 | 2 min read
By comparing stem cells from six mammals of different sizes, scientists discovered stark differences in embryonic development paces.
Researchers CHOOSE Organoids to Investigate Neurodevelopment
Deanna MacNeil, PhD | Jan 29, 2024 | 4 min read
A 3D variation of pooled CRISPR screens could connect the dots between autism spectrum disorder genetics and cell fate pathways in the developing brain.
New Stem Cell State
Anna Azvolinsky | Dec 10, 2014 | 3 min read
Through cellular reprogramming, researchers have produced a novel pluripotent mouse stem cell in vitro.
Study: MicroRNA, Retroviruses Coordinate to Influence Pluripotency
Joshua A. Krisch | Jan 13, 2017 | 2 min read
Removing a specific miRNA from stem cells may induce the expression of endogenous retroviruses that enable the cells to form extra-embryonic lineages.
Skipping Pluripotency
Jef Akst | Sep 14, 2011 | 5 min read
Researchers are developing ways to convert mature somatic cells from one cell type to another, avoiding the tumor-causing pluripotent stage associated with stem cells.

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