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tag induced pluripotent stem cell culture evolution cell molecular biology ecology

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Synthetic Circuits Reveal the Key to Rewinding the Cellular Clock
Charlene Lancaster, PhD | Mar 12, 2024 | 4 min read
Using a circuit-based system, scientists determined the ideal transcription factor levels to promote the successful reprogramming of fibroblasts into induced pluripotent stem cells.
Pluripotent Stem Cell Culture: Challenges and Strategies
The Scientist Marketing Team | May 6, 2015 | 1 min read
The Scientist brings together a panel of experts to discuss challenges and strategies for optimizing your pluripotent stem cell culture.
Biology’s New Supermodel
Megan Scudellari | Jul 20, 2011 | 5 min read
Induced pluripotent stem cells are biology’s hottest new tool for understanding human disease.
Artist’s rendition of a blue-green DNA double helix, viewed lengthwise from within one end.
Stem Cell Lines Riddled With Undetected Mutations
Dan Robitzski | Aug 12, 2022 | 4 min read
Most of the human induced pluripotent stem cells stored at major cell line repositories and used in research harbor thousands of DNA errors, a study finds, highlighting the need for improved quality control measures.
Using CRISPR to Edit Genes in Induced Pluripotent Stem Cells
Kelly Rae Chi | Sep 1, 2016 | 8 min read
Tips on how to surmount the challenges of working with CRISPR to manipulate genes in human stems cells to study their function in specific diseases or to correct genetic defects in patient cells.
Modeling the Human Lung with Organoids
The Scientist Creative Services Team in collaboration with MilliporeSigma | Mar 29, 2021 | 3 min read
A new specialized cell culture media system generates induced pluripotent stem cell-derived lung organoids that more closely resemble the diversity of cell types found in the human lung.
A close up of a tick held in a pair of forceps, with Kevin Esvelt’s face out of focus in the background.
CRISPR Gene Drives and the Future of Evolution
Hannah Thomasy, PhD | Mar 15, 2024 | 10+ min read
Genetic engineering pioneer Kevin Esvelt’s work highlights biotechnology’s immense potential for good—but also for catastrophe.
Stem cells for brain cancer
Peter B. Dirks | Apr 1, 2006 | 3 min read
FEATUREThe Ecology of Tumors Stem cells for brain cancer BY PETER B. DIRKSNeural stem cell biology took off in 1992 when Brent Reynolds and Samuel Weiss, working at the University of Calgary, discovered that culturing mammalian brain cells in serum-free conditions (in EGF and bFGF), yielded clonally derived colonies of undifferentiated neural cells (neurospheres). This culture system demonstrated that cells within these colonies showed cardinal pr
Skipping Pluripotency
Jef Akst | Sep 14, 2011 | 5 min read
Researchers are developing ways to convert mature somatic cells from one cell type to another, avoiding the tumor-causing pluripotent stage associated with stem cells.
Combating COVID-19 with Cell-Free Expression
The Scientist | Aug 19, 2020 | 6 min read
Scientists rely on synthetic biology and cell-free expression systems for developing novel approaches to combat the pandemic.

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