Dropping the transcription factor from the four so-called Yamanaka factors reduces the efficiency of inducing the production of stem cells, but the resulting cells are of greater quality.
Activating genes for reprogramming factors for a short time transforms large numbers of differentiated cells into multipotent forms that could be useful for cell-based therapies.
Since The Scientist published its first issue in October 1986, life-science research has transformed from a manual and often tedious task to a high-tech, largely automated process of unprecedented efficiency.
In the midst of news that engineered organs are being implanted into animals and people, researchers announce the creation of artificial blood for transplant.
An investigating committee at Japan’s RIKEN research center finds evidence of falsification and fabrication in two recent Nature papers that touted a new way to induce pluripotency.
A group of microRNAs can inhibit the formation of induced pluripotent stem cells, and may provide a target for more efficient reprogramming of somatic cells.