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Cancer Research in Flames

By Michael Karin(karinoffice@ucsd.edu) | December 5, 2005

One problem with the current war on cancer is that much of it focuses on destroying the malignant cell itself while paying little attention to some of cancer's allies that are more prone to attack.

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Mining the Ubiquitin Pathway

By John Hall(hall@lifesensors.com) | December 5, 2005

In October 2004, the Royal Swedish Academy of Sciences awarded the Nobel Prize in Chemistry to Aaron Ciechanover, Avram Hersko, and Irwin Rose "for the discovery of ubiquitin-mediated protein degradation."

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Protein Solution Structure in Three Days or Less?

By John Markley(markley@nmrfam.wisc.edu) | December 5, 2005

More efficient protein structure determination is a major goal of the US structural genomics projects.

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Merging Companies Safely

By William Gaede | November 21, 2005

Every life scientist practices due diligence.

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How Do We Look?

By Matteo Carandini(matteo@ski.org) | November 7, 2005

Since long before the word neuroscience was coined, the community has devoted substantial resources to studying the visual system, and for good reason.

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Minding the Drug Development Gap

By Edward Spack | November 7, 2005

Twenty-five years after the enactment of the Bayh-Dole Act, scientists and administrators in academia who are interested in moving bench discoveries to the clinic are learning what travelers in London's subway system already know: It's important to "mind the gap."

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On Human Diversity

By Armand Leroi(a.leroi@ic.ac.uk) | October 24, 2005

Henry Flower became director of the British Museum of Nat ural History in 1884, and promptly set about rearranging exhibits.

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The Protein Structure Initiative, Five Years Later

By John Norvell(norvellj@nigms.nih.gov) | October 24, 2005

Five years have passed since the National Institutes of Health launched the Protein Structure Initiative (PSI), a 10-year, $600 million effort to accelerate structural genomics.

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DNA Damage Responses: Cancer and Beyond

By Michael Kastan(michael.kastan@stjude.org) | October 10, 2005

The composition and sequence of 3 billion bases of DNA serve as a major determinant of our individual physiology.

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How to Find New Antibiotics

By Jo Handelsman(joh@plantpath.wisc.edu) | October 10, 2005

We need new antibiotics.

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