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Evolutionary Teamwork

By Frederic Bushman | May 10, 2004

Frederic D. BushmanCourtesy of Frederic D. BushmanThe endosymbiotic theory, which posits that organelles such as chloroplasts and mitochondria descended from formerly independent cells, has received wide acceptance in the last third of the 20th century. But recent findings suggest that endosymbiotic processes may have contributed still more cellular components, chloroplasts and mitochondria being simply the most easily identified examples.Genomic analyses across a broad spectrum of organisms hav



By Leonard Guarente | April 26, 2004

WITHSTANDING FEAST AND FAMINE:Courtesy of Leonard P. GuarenteYeast form dormant spores during times of starvation in order to survive for future times of plenty. The cycle between diploid a/α cells and haploid spores is regulated by SIR2 and the related gene HST1.Since the dawn of consciousness, humans have been in a unique position to contemplate their own mortality. While this exercise has been a boon to philosophical musings, it has not led to any real scientific progress in understandin


Organellar Proteomics

By Matthias Mann | April 12, 2004

For nearly 300 years, cell biology has been largely an observational science. Robert Hooke in 1665 saw structures under the microscope that he called cells. Anthony van Leeuwenhoek discovered cellular substructures in 1700, which Robert Brown dubbed 'nuclei' in 1833. Cell biologists have described many other substructures since then, the most prominent among them being the mitochondria, Golgi apparatus, endoplasmic reticulum, and nucleolus.With the advent of molecular biology, cell biologists we


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