cell & molecular biology, cancer

Metastatic cancer cells use nanotubes to manipulate blood vessels.

Cancer cells exhibit altered metabolic processes that may serve as promising targets for new therapies.

A tumor’s physical environment fuels its growth and causes treatment resistance.

How cancer cells fuel their rapid growth

The causes and consequences of physical forces in the tumor microenvironment

Questions about how E. coli evolves; spermatids in a dish; fighting bacteria with virus-like molecule; what drives metastasis; antibodies fight Ebola in monkeys

Clinical cases link immune changes to a cancer’s spread through the body, but find no role for so-called “driver” mutations.

Obese people are at higher risk for developing cancer, have worse prognoses once diagnosed, and are often resistant to chemotherapy regimens. The question is, Why?

Mice given a dietary supplement had faster-progressing melanoma, a study shows.

Two studies reveal that the giant mammals have dozens of extra copies of a cancer-preventing gene.

Despite known problems with contamination and mislabeled cell lines, most researchers continue to operate without authenticating cells’ identity.

Cytoskeleton specialist Alan Hall was best known for unpacking the roles of Rho GTPases.   

Activating signaling pathways, rather than individual genes, reveals roles for both growth and dedifferentiation in establishing resistance to cancer treatments.

In estrogen receptor–positive breast cancer, the transcription factor IRF1 tips the balance between cellular suicide and survival through autophagy.

The tale of p53, a widely studied tumor suppressor gene, illustrates the inventiveness of researchers who turn mishaps into discoveries.

Treating cancer by shutting down the alternative lengthening of telomeres (ALT) pathway

Fate mapping allows researchers to follow cancer progression from its cell type of origin.

If one out of three people develops cancer, that means two others don’t. Understanding why could lead to insights relevant to prevention and treatment.

Scientist to Watch Yvonne Saenger explains recent advances in using biomarkers to identify cancer patients who might benefit most from immunotherapy.

In Chapter 12, "Of Mice and Men," author Sue Armstrong recounts the point at which researchers moved from working with p53 in tissue culture to studying the gene in animal models.