disease & medicine, immunology

An enzyme of the bacteria Porphyromonas gingivalis has been found in the brains of patients with the disorder, and causes neurodegeneration in mice.

The head of the National Institute of Arthritis and Musculoskeletal and Skin Diseases was a leader in the study of skin-based immunology.

A study finds the effect is dose-dependent, with each additional pet further lowering the odds of developing allergies.

Numerous experimental vaccines that aim to provide multi-season protection are in human studies.

This year’s winners also include the developers of nusinersen, an oligonucleotide therapeutic for spinal muscular atrophy.

Some patients could suppress the virus without antiretroviral therapy for months after the drug infusions.

Nine of the most recent retractions from AACR journals are for papers coauthored by embattled cancer researcher Bharat Aggarwal.

The promise of immunotherapy is real. We now need to figure out how to maximize the number of patients the approach benefits.

Stem-cell–derived natural killer cells engineered in a similar way to CAR-T cells may pave the way to “off the shelf” cancer therapies that aren’t patient-specific.

A study of Shuar children in Ecuador provides a window into how the human body responds to infection in the sorts of conditions that shaped our species’ evolution.

Vaccination reduced the risk of death by two-thirds for children with no other health problems.  

The receptors, found in so-called elite controllers who don’t need medications to keep the virus in check, suggest a new path toward immunotherapy.

Drugs approved to treat rheumatoid arthritis block cytokines, the molecules responsible for severe side effects from the immunotherapy, and reduce symptoms in mice.

The immunotherapy eliminated a woman’s metastatic lesions and kept her disease-free for two years.

Merck’s Keytruda extended the lives of lung cancer patients by several months and appeared to stop the progression of advanced melanoma.  

Researchers found a previously undiscovered hepadnavirus in an immunocompromised cat.