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Upping a gene’s expression in rat brains made them better learners and normalized the activity of hundreds of other genes to resemble the brains of younger animals.

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Activating genes for reprogramming factors for a short time transforms large numbers of differentiated cells into multipotent forms that could be useful for cell-based therapies.

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image: Corals’ pH Sensor Identified

Corals’ pH Sensor Identified

By | November 1, 2017

Soluble adenylyl cyclase measures and responds to pH changes in coral cells, but whether it can help the animals withstand ocean acidification is not yet known.

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With the arrival of a new class of single-nucleotide editors, researchers can target the most common type of pathogenic SNP in humans.

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image: Circadian Gene Linked to Severe Epilepsy in Children

Circadian Gene Linked to Severe Epilepsy in Children

By | October 11, 2017

Loss of the CLOCK protein, which researchers find is decreased in pediatric epilepsy patients, makes mice more prone to seizures during sleep.

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Neurons derived from human induced pluripotent stem cells fill in for lost dopamine neurons in a primate model of the disease.

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image: A Potential Remedy for the Aging Brain

A Potential Remedy for the Aging Brain

By | August 8, 2017

In mice, injected fragments of a naturally occurring protein boost memory in young and old animals and improve cognition and mobility in a model of neurodegenerative disease. 

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A new method stimulates B cells to make human antigen-specific antibodies, obviating the need for vaccinating blood donors or hunting for rare B cells.

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image: Gut Feeling

Gut Feeling

By | June 22, 2017

Sensory cells of the mouse intestine let the brain know if certain compounds are present by speaking directly to gut neurons via serotonin.

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image: Deep Brain Stimulation Without Surgery

Deep Brain Stimulation Without Surgery

By | June 1, 2017

Using interfering high-frequency currents applied to the surface of the mouse skull, scientists can noninvasively target brain regions buried below the cortical surface. 

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