Research round-up

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NEW YORK, August 3 (Praxis Press) The antipsychotic drug, Mellaril (thioridazine) has been shown to prolong patients' QTc interval, which can lead to a type of ventricular tachycardia known as torsades de pointes and potentially sudden death. At the request of the US Food and Drug administration (FDA), the manufacturer of the drug, Novartis, has now added a black box warning on the drug's label in order to alert physicians to its tendency of prolonging a patient's heartbeat interval. Now Mellari

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Thrombolytic therapy

August 8, 2000

NEW YORK, August 7 (Praxis Press) Thrombolytic therapy for acute myocardial infarction is equally effective when delivered as a bolus injection and as a 60 to 90-minute infusion; however, the relative safety of these two delivery methods is unknown. Using meta-analysis, Mehta and colleagues studied the risk of intracranial hemorrhage in patients receiving thrombolytic therapy as a bolus or as an infusion. The analysis included seven randomized trials with a total of 103,972 patients. The risk of

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Recommend a tuberculin skin test to patients returning from regions where tuberculosis is endemic.

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Breeding a better vector

By | August 7, 2000

DNA shuffling (also called molecular breeding) generates variation by random fragmentation of a cloned gene followed by reassembly of the fragments in a self-priming polymerase reaction. The result is a recombination of overlapping fragments that have different mutations or come from different, naturally occurring homologous genes. In the August Nature Genetics Soong et al apply this technique to a pool of six different murine leukemia virus envelope sequences to derive a new virus that can,

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Profiles of metastasis

By | August 7, 2000

DNA microarray analysis of metastatic cells reveals a new player, and an expression profile characteristic of reduced motility and invasive ability.

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The two chromosomes of cholera

By | August 7, 2000

suggests that the bacterium's second chromosome may have started life as a megaplasmid.

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Better evaluation of health risks associated with cell phones is necessary.

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Esophageal adenocarcinoma

August 3, 2000

Reflux-promoting drugs may raise risk for esophageal adenocarcinoma.

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Smoking and diabetes

August 3, 2000

NEW YORK, August 2 (Praxis Press) Ethnic and lifestyle factors may play a role in the relationship of cigarette smoking and the development of type 2 diabetes. Nakanishi and colleagues studied the association of smoking and the development of impaired fasting blood-glucose and type 2 diabetes in 1,266 middle-aged Japanese men. The relative risks of developing impaired fasting glucose and type 2 diabetes increased with the number of cigarettes smoked per day. Compared with never-smokers, men who

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NEW YORK, August 2 (Praxis Press) At least 40 cases of hepatic steatosis and lactic acidosis have been reported in HIV-infected patients taking zidovudine and didanosine, but this syndrome has only rarely been reported in patients taking stavudine. Miller and colleagues reported four cases of hepatic steatosis, lactic acidosis, and myopathy in HIV-infected patients taking stavudine as part of a multidrug antiretroviral regimen. All patients had marked lactic acidosis, elevated levels of alanine

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