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Researchers develop a new technique to selectively activate neurons deep in the rodent brain, taking a step toward noninvasive brain stimulation for neurological disorders.

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image: Top Technical Advances in 2017

Top Technical Advances in 2017

By Shawna Williams | December 25, 2017

The year’s most impressive achievements include new methods to extend CRISPR editing, patch-clamp neurons hands-free, and analyze the contents of live cells.

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image: CRISPR Helps Mice Hear

CRISPR Helps Mice Hear

By Abby Olena | December 20, 2017

Researchers reduce the severity of hereditary deafness in mice with the delivery of CRISPR-Cas9 protein-RNA complexes that inactivate a mutant gene in their inner ears. 

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image: New Resource Ranks Chemical Probes for Human Proteins

New Resource Ranks Chemical Probes for Human Proteins

By Abby Olena | December 14, 2017

With many probes being seriously flawed, Probe Miner helps researchers find those that are most specific and effective for manipulating their chosen proteins.

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Chemistry Nobel goes to Jacques Dubochet, Joachim Frank, and Richard Henderson. 

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image: Nonviral CRISPR Delivery a Success

Nonviral CRISPR Delivery a Success

By Abby Olena | October 2, 2017

Researchers use gold nanoparticles to deliver CRISPR-Cas9 and correct a point mutation in a mouse model of Duchenne muscular dystrophy. 

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image: Metabolomics Data Under Scrutiny

Metabolomics Data Under Scrutiny

By Ashley P. Taylor | September 15, 2017

Out of 25,000 features originally detected by metabolic profiling of E. coli, fewer than 1,000 represent unique metabolites, a study finds.

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image: Quantitating Glycans for Biomarker Discovery

Quantitating Glycans for Biomarker Discovery

By Amanda Keener | August 28, 2017

Techniques for comparing the relative abundances of glycans and glycoproteins in clinical samples

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image: Custom-Made Molecules

Custom-Made Molecules

By Ruth Williams | August 21, 2017

A new prototype machine can make the biological molecules of one’s choice from digital DNA sequences.

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image: Chemogenetics Doesn’t Work Like Many Thought

Chemogenetics Doesn’t Work Like Many Thought

By Kerry Grens | August 4, 2017

A study finds the so-called DREADD method of manipulating neurons using a drug called CNO actually works via clozapine.

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