cancer

An in situ map of copy number variations in prostate tissue reveals that purportedly cancerous genomic changes frequently occur in the healthy tissue surrounding tumors.

Disturbing circadian rhythms in organoids and mice increases intestinal tumor growth, findings that may explain a recent rise in colon cancer among young adults, the researchers behind the work say.

At Brigham and Women’s Hospital, the cancer biologist is combining research into the tumor microenvironment with the principles of neuroscience to tease apart how cancers grow—and how to stop them.

The announcement confirms earlier reports that Bertagnolli will become the first woman to lead the National Cancer Institute since its founding in 1937.

Neuron-like glioblastoma cells are the pioneers of deadly tumors’ spread through the brain, contributing to their devastating invasiveness, a study in mice finds.

A previously overlooked enzyme called APOBEC3A is linked to the most prevalent mutational signatures in cancer cell lines, a study finds.

A new benchtop microfluidic device generates patient-derived tumor micro-organospheres that allow for real-time cancer therapy decisions.

Head and neck cancer cells lacking the peptide involved in energy production were less likely to metastasize in mice.

Scientists found that combining the notoriously flimsy anticancer protein p53 with a domain from a spider silk protein resulted in a more stable hybrid that’s more potent and easier for cells to synthesize.

A new CRISPR screening technology allows scientists to recreate tumor heterogeneity in vivo and study how it affects all aspects of cancer biology.

Dormant cancer cells and dysfunctional immune cells living together in a tumor niche form a therapy-resistant reservoir.

More cancer cells are shed from primary tumors when individuals are asleep than when they’re awake, according to observations in mouse models and a small cohort of breast cancer patients.

A study reveals a molecular pathway linking exercise to an amped-up immune response to pancreatic cancer and greater responsiveness to treatment.

A technique for quantifying tumor mRNA production from messy tissue sample data uncovers an unexpected correlation between it and disease stage in 15 cancer types.