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image: Monitoring Mutations with Microfluidics

Monitoring Mutations with Microfluidics

By Ruth Williams | March 15, 2018

A device dubbed the “mother machine” enables real-time observation of mutagenesis in single bacterial cells.  


image: Stem Cell Vaccine Protects Mice From Cancer

Stem Cell Vaccine Protects Mice From Cancer

By Ruth Williams | February 15, 2018

Stem cells and cancer cells have enough molecular similarities that the former can be used to trigger immunity against the latter.

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The findings more than double the number of known defense mechanisms, piquing the interests of molecular biology tool developers.


Activating genes for reprogramming factors for a short time transforms large numbers of differentiated cells into multipotent forms that could be useful for cell-based therapies.


image: Corals’ pH Sensor Identified

Corals’ pH Sensor Identified

By Ashley P. Taylor | November 1, 2017

Soluble adenylyl cyclase measures and responds to pH changes in coral cells, but whether it can help the animals withstand ocean acidification is not yet known.


image: Opinion: How to Define Cell Type

Opinion: How to Define Cell Type

By Sara B. Linker, Tracy A. Bedrosian, and Fred H. Gage | November 1, 2017

Advances in single-cell technologies have revealed vast differences between cells once thought to be in the same category, calling into question how we define cell type in the first place.


With the arrival of a new class of single-nucleotide editors, researchers can target the most common type of pathogenic SNP in humans.

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image: The Ever-Expanding T-Cell World: A Primer

The Ever-Expanding T-Cell World: A Primer

By Ashley P. Taylor | August 7, 2017

Researchers continue to identify new T-cell subtypes—and devise ways to use them to fight cancer. The Scientist attempts to catalog them all.


image: Fascinated by Folding

Fascinated by Folding

By Anna Azvolinsky | August 4, 2017

Lila Gierasch uses biochemical tools to understand how linear chains of amino acids turn into complex three-dimensional structures.

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A new method stimulates B cells to make human antigen-specific antibodies, obviating the need for vaccinating blood donors or hunting for rare B cells.


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