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Red blood vessels that decrease in diameter as they radiate outward are pictured on a pink and white surface
Antisense Oligonucleotides Cross Rodents’ Blood-Brain Barrier
RNA-DNA complexes that were modified with cholesterol made it into the brains of rats and mice, where they knocked down target genes.
Antisense Oligonucleotides Cross Rodents’ Blood-Brain Barrier
Antisense Oligonucleotides Cross Rodents’ Blood-Brain Barrier

RNA-DNA complexes that were modified with cholesterol made it into the brains of rats and mice, where they knocked down target genes.

RNA-DNA complexes that were modified with cholesterol made it into the brains of rats and mice, where they knocked down target genes.

disease & medicine, genetics & genomics

GWAS, psychotic disorder, mood disorder, Q&A, bipolar disorder, schizophrenia, depression, sex differences
Genetic Variants Tied to Sex Differences in Psychiatric Disorders
Amanda Heidt | Mar 31, 2021 | 5 min read
The largest study of its kind identifies single nucleotide polymorphisms with disparate effects on men’s and women’s susceptibility to conditions such as bipolar disorder and schizophrenia.
Mary Jeanne Kreek, heroin, addiction, methadone, drug addiction, The Rockefeller University,
Mary Jeanne Kreek, Methadone Developer, Dies at 84
Asher Jones | Mar 31, 2021 | 2 min read
A physician and neurobiologist at the Rockefeller University who specialized in addiction research, Kreek was best known for her work on developing the treatment for heroin addiction.
early-life stress, histone, chromatin, epigenetics, epigenetic modification, methylation, DNA, protein, stress, adversity, mice, genetics, genomics
Early-Life Stress Exerts Long-Lasting Effects Via Epigenome
Asher Jones | Mar 18, 2021 | 5 min read
In mice, epigenetic marks made on histones during infancy influence depression-like behavior during adulthood. A drug that reverses the genomic tags appears to undo the damage.
Gene Therapy for Sickle Cell Not Linked to Cancer, Bluebird Finds
Lisa Winter | Mar 11, 2021 | 2 min read
Clinical trials were halted after the treatment’s vector that ferries in the healthy genetic sequence was identified in the genome of a patient’s cancer cells.
Interim Report on Origin of SARS-CoV-2 Scrapped by WHO
Lisa Winter | Mar 5, 2021 | 2 min read
Instead, the full report will be available in mid-March.
Variant Found in Brazil Could Evade Immunity from Past Infection
Lisa Winter | Mar 2, 2021 | 2 min read
The P.1 variant, which has also been detected in five US states, could be responsible for cases of reinfection, according to a preprint.
COVID-19, SARS-CoV-2, coronavirus, pandemic, virus, B.1.1.7, B.1.525, variant, UK
Another Potentially Immunity-Evading SARS-CoV-2 Variant Detected
Asher Jones | Feb 16, 2021 | 2 min read
B.1.525 shares a mutation with the B.1.351 variant first detected in South Africa that seems to allow the virus to dodge the immune system.
SARS-CoV-2 with Genomic Deletions Escapes an Antibody
Abby Olena, PhD | Feb 16, 2021 | 4 min read
Researchers identify deletions in the N-terminal domain of the spike protein that allow the coronavirus to avoid antibody neutralization and that may contribute to the emergence of new variants.
Respected Medical Geneticist Sir Peter Harper Dies at 81
Catherine Offord | Feb 2, 2021 | 4 min read
The Cardiff University researcher was famous both for his work on genetic disorders and for his documentation of the history of his field.
Are Phages Overlooked Mediators of Health and Disease?
Catherine Offord | Feb 1, 2021 | 10+ min read
Bacteria-infecting viruses affect the composition and behavior of microbes in the mammalian gut—and perhaps influence human biology.
Infographic: Trans-kingdom Interactions in the Gut
Catherine Offord | Feb 1, 2021 | 1 min read
Phages interact with bacteria and eukaryotic cells in ways that researchers suspect influence mammalian health.
New SARS-CoV-2 Variant Could Evade Antibodies
Lisa Winter | Jan 22, 2021 | 3 min read
A preprint casts doubt on vaccine effectiveness in light of certain mutations in the 501Y.V2 variant that emerged from South Africa.
COVID-19, SARS-CoV-2, coronavirus, pandemic, variant, L452R, B.1.1.7, virus,
Coronavirus Variant Linked to COVID-19 Outbreaks in California
Asher Jones | Jan 19, 2021 | 2 min read
It’s too early to know whether the L452R version of SARS-CoV-2 is highly infectious like the B.1.1.7 UK variant that is also spreading around the US.
brown fat, metabolism, cardiovascular disease, cardiometabolic disease, genetics & genomics, immunology, Q&A, adipose tissue, obesity
Q&A: Brown Fat Linked to Better Cardio and Metabolic Health
Amanda Heidt | Jan 12, 2021 | 5 min read
Paul Cohen of the Rockefeller University describes his study of thousands of people, finding that the energy-burning tissue is tied to a lower risk of for several diseases, including type 2 diabetes, high blood pressure, and heart disease.
Identical Twins Accumulate Genetic Differences in the Womb
Catherine Offord | Jan 7, 2021 | 4 min read
DNA replication errors during cell division cause monozygotic twins to diverge from each other even during the earliest stages of development, a new study finds.
Your Partner’s Genome May Affect Your Health
Catherine Offord | Jan 5, 2021 | 4 min read
A study using data from more than 80,000 couples finds evidence of indirect genetic effects on traits ranging from smoking habits to mental health.
South African SARS-CoV-2 Variant Alarms Scientists
Max Kozlov | Jan 5, 2021 | 3 min read
An additional mutation in the spike protein of the coronavirus may help it elude antibody recognition, and scientists are investigating if current vaccines will protect against it.
First US Case of UK SARS-CoV-2 Variant Detected
Max Kozlov | Dec 30, 2020 | 4 min read
Variant B.1.1.7, though likely more contagious than other strains, does not appear to be more deadly.
Eight Proteins Turn Mouse Stem Cells into Egglike Cells
Ashley Yeager | Dec 16, 2020 | 3 min read
The identification of the transcription factors that elicit oocyte growth will aid reproductive biology research and might help women with fertility issues, scientists say.  
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