genetics & genomics, disease & medicine

One variant limited the brain’s ability to use glucose.

Researchers used TALENs and zinc finger nucleases to correct disease-causing mutations.

The researchers catalogued 3,893 variants of the gene implicated in cancer using CRISPR.

Molecules similar to those produced by sea anemones are neuroprotective in a mouse cell model of Alzheimer’s disease.

The Germany-based study will test an ex vivo genome-editing therapy for the inherited blood disorder β-thalassemia.

Researchers boosted levels of the dystrophin protein to nearly normal levels in a canine model of the disease.

A double gene-transfer therapy transformed the non-neuronal cells into rod photoreceptors in the retinas of animal models of congenital blindness.

The cell type was discovered via single-cell RNA sequencing of thousands of cells in mouse and human airways and may play a role in cystic fibrosis.

Scientists have engineered swine that pollute less, fend off disease, and produce more meat, but you won’t find them outside experimental farms . . . yet.

The DNA-cutting enzyme used in the technique is not as precisely targeted as scientists had thought, and investors take notice.

Brief electroporation appears to make T cells more receptive to new genetic material, which could speed the development of immunotherapies.

Machine-learning algorithms tuned to detecting cancer DNA in the blood could pave the way for personalized cancer care.

In the largest-ever study of its kind, researchers combined genomic data from nearly 900,000 patients and healthy individuals to identify commonalities among 10 mental illnesses.

Preliminary data from Sarepta Therapeutics has exceeded expectations, causing a surge in company stock prices this week.

Researchers discover that a layer of human breast tissue is not one but two distinct cell types.  

They may be a prospective source for an influenza pandemic, researchers warn.  

The bat version of the STING protein helps dampen the mammals' immune response to infection, researchers have found.

Genetic adaptations for human brain development also make us vulnerable to Alzheimer’s disease, according to a new study.  

Complications during pregnancy may act via the placenta to magnify the effects of genetic risk factors.