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T cells keep the memory alive

By | August 21, 2002

The discovery of T cell functional plasticity could help treat autoimmune disorders and cancer.

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Transgene switch

By | August 21, 2002

The ability to regulate transgene expression levels is essential for many functional genomic and therapeutic applications. In an Advanced Online Publication in Nature Biotechnology, Wilfried Weber and colleagues describe the development of E.REX, a novel gene regulation system that exploits components of the Escherichia coli erythromycin-resistance regulon (Nat Biotechnol 2002, DOI:10.1038/nbt731).They designed both EOFF and EON systems that are respectively repressed or induced using macrolide

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Distinct Ras requirements

By | August 20, 2002

Ras oncogenesis differs between human and mouse cells.

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Failure for EGFR inhibitor

By | August 20, 2002

AstraZeneca releases disappointing results from trials of Iressa, a promising cancer drug.

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New, tacky oncogenes

By | August 20, 2002

Nr-CAM, a neuronal cell adhesion molecule, plays a role in melanoma and colon cancer.

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Lawyers oppose ban on cloning

By | August 19, 2002

American Bar Association votes to oppose government ban on therapeutic cloning.

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RNA effective against brain cancer

By | August 19, 2002

dependent protein kinase can inhibit glioblastoma growth.

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Small detail makes big difference

By | August 19, 2002

A single amino acid residue largely determines human ABO blood groups.

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Detecting allelic variations in expression

By | August 16, 2002

A new method allows quantitative assessment of allelic variations in gene expression.

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NO and neuronal cell death

By | August 16, 2002

Neuronal apoptosis in stroke is in part mediated by NO-activated matrix metalloproteinases.

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