Single-cell genome analyses reveal the amount of mutations a human brain cell will collect from its fetal beginnings until death.
June 14, 2002|
Fanconi Anemia (FA) is a recessive cancer susceptibility syndrome. Six FA genes have been cloned and encode proteins involved in a DNA-damage response pathway. In the June 13 ScienceXpress, Niall Howlett and colleagues report the characterization of mutations in cells from the FA subtypes B and D1 (ScienceXpress 2002, DOI:10.1126/science.1073834).They discovered biallelic mutations in the BRCA2 breast cancer susceptibility gene; the mutations create frameshifts resulting in truncated BRCA2 prote