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Choosing the X

By | May 13, 2002

Inactivation of one of the two X chromosomes in females is regulated by sequences on the X-chromosome within the X inactivation center (Xic). In the May 10 Science, Percec et al. report the identification of trans-acting autosomal elements involved in choosing the particular X chromosome for inactivation (Science 2002, 296:1136-1139).They performed a phenotype-driven genetic screen for mutations that affect X-chromosome silencing choices in mice: they screened mice from parents exposed to chemic

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IGF-I may heal diabetes

By | May 13, 2002

cells regenerates pancreatic islets and leads to recovery from type 1 diabetes.

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Choosy stem cell migration

By | May 10, 2002

but not to chemokines signaling through other chemokine receptors.

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Housekeeping clusters

By | May 10, 2002

Operons, clustered groups of co-expressed genes, are well known in prokaryotes, but few examples exist in eukaryotic organisms. The availability of extensive transcriptome and genomic data for many eukaryotes is encouraging researchers to look more closely for clusters of co-regulated genes in higher organisms. In an Advanced Online Publication in Nature Genetics Martin Lercher and colleagues at the University of Bath, UK, report the existence of clusters of housekeeping genes in the human genom

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Anthrax genomics

By | May 9, 2002

The threat of bioterrorism has renewed interest in techniques for pathogen detection, monitoring and analysis. In the May 8 ScienceXpress, Timothy Read and researchers at The Institute for Genome Research (TIGR) Maryland, USA, describe a genome-based analysis of Bacillus anthracis, the causative agent of anthrax (DOI:10.1126/science.1071837).Read et al. assembled sequences from a recent isolate of B. anthracis used in a series of fatal letter-based attacks in Florida that followed in the wake of

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Smallpox debate flares again

By | May 9, 2002

World Health Assembly to decide whether to keep or destroy deadly virus.

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Streptomyces coelicolor genome

By | May 9, 2002

genome reveals many of the adaptations necessary for life in the highly competitive soil environment.

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Annotation by SAGE

By | May 8, 2002

The inventors of SAGE technology describe a modified method to facilitate gene discovery.

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The weak point of PEO

By | May 8, 2002

causes error-prone DNA synthesis in progressive external ophthalmoplegia.

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Display of targets in multiple sclerosis

By | May 7, 2002

Gene-microarray analysis of multiple sclerosis lesions reveals molecular mechanisms and new therapeutic targets.

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