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New vaccine hopes for cancer

By | April 5, 2002

Tumor cells covered with a T cell ligand-mimicking antibody fragment can initiate their own destruction.

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The genome that feeds the world

By | April 5, 2002

Two independent groups report draft sequences of the rice genome.

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The silencing team

By | April 5, 2002

Inactivation of tumor suppressor genes is an essential stage in the development of human cancer but the extent of the involvement of epigenetic silencing and hypermethylation in this process remains unclear. In April 4 Nature, Ina Rhee and colleagues from Johns Hopkins University School of Medicine, show that two enzymes (DNMT1 and DNMT3b) cooperate to silence genes and maintain DNA methylation in human cancer cells.Rhee et al. worked on a colorectal cancer cell line and observed that only genet

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Maternal antibodies and diabetes

By | April 4, 2002

reactive autoantibodies prevents diabetes in nonobese diabetic mice.

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Protein polymorphisms

By | April 4, 2002

In an Advanced Online Publication from Nature Genetics, Klose at al. describe a comprehensive genetic study of proteins in the murine brain (Nat Genet 2002, DOI:10.1038/ng861).They took advantage of crosses from the European collaborative interspecific backcross (EUCIB) project, and prepared brain tissues from 200 backcross progeny (B1) animals. Klose at al. then analyzed the brain proteome using two-dimensional gel electrophoresis. Comparison of over 8000 gel spots from two distantly related mo

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Publication with a pinch of privatisation

By | April 4, 2002

yet again bends the rules in publishing the rice genome, opinions are strongly divided on whether this should be the shape of things to come.

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Ultrasound vision improved

By | April 4, 2002

A miniaturized, ultrasound transducer system can examine small areas of tissue and obtain sharp, well-defined images.

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Prostaglandin's colon repair receptor

By | April 3, 2002

Nonsteroidal anti-inflammatory drugs increase the severity of human inflammatory bowel disease (IBD), but little is known about the mechanisms by which prostanoid inhibition modulates IBD. In April 1 Journal of Clinical Investigation, Kenji Kabashima and colleagues from Kyoto University, Kyoto, Japan, show that the prostaglandin receptor EP4 has a key role in mucosal protection, suppressing colitis, mucosal damage and CD4 cell activation in the gut.Kabashima et al. examined mice deficient in pro

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Serotonin vital for anxious adulthood

By | April 3, 2002

receptor acts during development to establish normal anxiety-like behavior in the adult.

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Strep genomics

By | April 3, 2002

Group A Streptococcus (GAS) infection by serotype M18 strains causes acute rheumatic fever (ARF) and can lead to pediatric heart disease. In the April 2 Proceedings of the National Academy of Sciences, James Smoot and colleagues at the National Institute of Allergy and Infectious Diseases report the genome sequence of a GAS strain (MGAS8232) isolated from a patient with ARF (Proc Natl Acad Sci USA 2002, 99:4668-4673).Smoot et al. compared the 1.9 Mb genome with a closely related strain (the M1 s

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