The 10-micrometer-long flagellate cell might have a big story to tell about the evolution of eukaryotes.
March 21, 2002|
In the March 19 Proceedings of the National Academy of Sciences, Mohammed Kashani-Sabet and colleagues describe the use of plasmid-based ribozymes as functional genomics tools to unravel complex phenotypes, such as cancer metastasis (Proc Natl Acad Sci USA 2002, 99:3878-3883).Kashani-Sabet et al. reasoned that ribozyme-based gene targeting in mice might overcome experimental problems associated with transgenesis and lethal knockout phenotypes. They tested the use of systemic administration of ca