The 44-year-old patient has Hunter syndrome, which doctors hope to treat using zinc finger nucleases.
March 12, 2002|
Psoriasis is a chronic skin inflammation that may involve bacterial superantigens, but the inflammatory mechanisms and T cell responses remain poorly understood. In March 1 Journal of Clinical Investigation Thomas Zollner and colleagues from JW Goethe University of Frankfurt, Germany, show that proteasome inhibition reduces superantigen-mediated T cell activation and the severity of psoriasis in a SCID-hu model.Zollner et al. used human psoriatic skin tissue engrafted onto mice and observed that