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Endopeptidase modulated autoimmunity

By | January 14, 2002

Dominant myelin basic protein epitopes prevents autoimmunity and can be hidden from T cells by the action of asparagine endopeptidase.

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Finding the bug in the system

By | January 14, 2002

Computational subtraction uses the human genome to detect possible microbial causes for infectious diseases.

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Genetics of progressive osseous heteroplasia

By | January 14, 2002

mutations cause progressive osseous heteroplasia.

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Keeping an eye on gene expression

By | January 14, 2002

The retina contains neuronal cells (including photoreceptors) and non-neuronal retinal pigment epithelium (RPE). In January 8 Proceedings of the National Academy of Sciences, Dror Sharon and colleagues at Harvard Medical School describe characterisation of gene expression profiles in the human eye using the SAGE (serial analysis of gene expression) technology (Proc Natl Acad Sci USA 2002, 99:315-320).They prepared SAGE libraries from the peripheral retina, the macula and the RPE of two individua

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Placebo response not all in the mind

By | January 11, 2002

Imaging the brain during drug or placebo treatment for depression shows different but similarly effective responses.

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Py235 profiles

By | January 11, 2002

The Plasmodium yoelii yoelli genome contains around 35 genes encoding 235 kD rhoptry proteins (Py235) that are involved in erythrocyte invasion and parasite virulence. In the January 11 issue of Science, Preiser et al. describe the transcription pattern of py235 genes during the parasite's life cycle and their role in cell invasion (Science 2002, 295:342-345).Immunofluorescence analysis using antibodies recognizing distinct Py235 proteins revealed differences between pre-erythrocytic and erythro

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The anti-inflammatory effect of apoptotic bodies

By | January 11, 2002

1 secretion, resulting in accelerated resolution of inflammation.

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First link between air pollutants and birth defects

By | January 10, 2002

Pregnant women exposed to high levels of air pollution have increased likelihood of neonatal cardiac defects.

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Natural remedy for vision loss

By | January 10, 2002

Pathological angiogenesis can cause loss of vision and is associated with many diseases of the eye for which there exists no effective treatment. In January 8 Proceedings of the National Academy of Sciences, two papers by teams from The Scripps Research Institute, La Jolla, USA, described the unexpected antiangiogenic activity of a fragment of the human protein tryptophanyl-tRNA synthetase (TrpRS), a molecule also known to be involved in protein synthesis and cell proliferation. Atsushi Otani an

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Stretch DANCE

By | January 10, 2002

Extracellular elastic fibers are central to effective organ function, but the molecules that control the formation of these elastic fibers remains unclear. Two papers in January 10 Nature showed that the protein called fibulin-5 (also known as DANCE) is an elastin-binding protein essential for in vivo elastic fiber development.Hiromi Yanagisawa and colleagues from University of Texas Southwestern Medical Centre, Dallas, observed that fibulin-5 knockout mice developed marked elastinopathy owing t

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