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Genomic systems biology

By | November 23, 2001

Identifying genes linked to complex multifactorial diseases presents a formidable challenge for the post-genomic era. In the November 23 issue of Science, Monika Stoll and researchers at the Medical College of Wisconsin in Milwaukee describe a 'physiological profiling' strategy to investigate systems biology (Science 2001, 294:1723-1726).They measured 239 cardiovascular and renal phenotypes, during normal and stressed conditions, in 113 male rats derived from an F2 intercross. They could map 81

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Parasites bare all

By | November 23, 2001

The completion of a microsporidian parasite genome could have important implications for microbial comparative genomics.

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Skin antibiotics

By | November 23, 2001

Cathelicidin and dermicin are antimicrobial proteins that enhances skin defense against invasive bacteria.

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Anthrax attacks highlight holes in US public health system

By | November 22, 2001

The bioterrorist activity in the United States has identified significant gaps in the supposed seamless and coherent response to major public health emergencies.

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Genetic classification of lung tumors

By | November 22, 2001

DNA microarray studies of crudely dissected lung tumors can detect tumor subtypes that correlate with biological and clinical phenotypes.

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Radiation resistance

By | November 22, 2001

A screen of diploid yeast mutants has identified over a hundred genes involved in the response to ionizing radiation.

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Fly SNPs

By | November 21, 2001

genome will accelerate the rate of positional cloning in flies.

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Microbial biology to yield biomedical harvest

By | November 21, 2001

New initiatives launched by the US Department of Energy aim to extract practical benefits from the vast amount of microbial genomic data available.

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Molecular control of sleep

By | November 21, 2001

Levels of cAMP and cAMP response-element binding protein (CREB) control the balance between rest and wakefulness.

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Cholesterol keeps HIV-1 production healthy

By | November 20, 2001

HIV-1 multiplication requires the presence of cholesterol-enriched microdomains, in the plasma membrane of host cells.

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