Single-cell genome analyses reveal the amount of mutations a human brain cell will collect from its fetal beginnings until death.
September 26, 2001|
Transposon-based technology for insertional mutagenesis of the genome has been widely used in Drosophila and could be adapted for genomic analysis in mammals. Minos is a mobile element of the Tc1/mariner superfamily isolated from Drosophila hydrei. In the September 25 Proceedings of the National Academy of Sciences, Zagoraiou et al. report the use of Minos transposons in mouse tissues (Proc Natl Acad Sci USA 2001, 98:11474-11478).They generated two transgenic mouse lines: one expressing the Mino