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New York, June 30, 2000 (Praxis Press) Mortality rates from coronary artery disease (CAD), abnormal ventricular function and unsustained ventricular tachycardia are high. In patients with a history of myocardial infarction, cardiac arrest is often the result of reentrant ventricular tachycardia or fibrillation. Studies have not clearly assessed the prognostic value of electrophysiologic testing for these cases. In the Multicenter Unsustained Tachycardia Trial, Buxton et al performed electrophys

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New York, June 30, 2000 (Praxis Press) In familial adenomatous polyposis (FAP), a genetic disease that spurs the formation of hundreds of adenomatous polyps in the colon, the risk of developing colorectal cancer verges on 100 percent. Nonsteroidal antiinflammatory drugs (NSAIDs) are linked to a lower incidence of adenomatous polyps and lower colon cancer mortality, possibly due to their inhibition of the cyclooxygenase enzyme family, but their gastrointestinal toxicity limits their long-term use

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Disease is killing 160 times more people than major disasters

By | June 30, 2000

The International Federation of Red Cross and Red Crescent Societies, best known for its very visible work in short-term humanitarian disasters, has made a dramatic shift to the longer view - where disease is the great killer.Releasing its latest annual report this week, the Societies say that the death toll from infectious diseases such as AIDS, malaria, respiratory diseases and diarrhoea is 160 times greater than the number killed in last year's natural disasters, including the massive earthqu

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Update on the global AIDS epidemic (Africa)

By | June 30, 2000

Small signs of hope amidst increasing gloom. That's the world AIDS situation according to UNAIDS.

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Update on the global AIDS epidemic (Asia)

By | June 30, 2000

Small signs of hope amidst increasing gloom. That's the world AIDS situation according to UNAIDS.

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Update on the global AIDS epidemic (Latin America)

By | June 30, 2000

Small signs of hope amidst increasing gloom. That's the world AIDS situation according to UNAIDS.

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Update on the global AIDS epidemic (The newly independent states)

By | June 30, 2000

Small signs of hope amidst increasing gloom. That's the world AIDS situation according to UNAIDS.

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Warfarin and cancer

June 30, 2000

New York, June 30, 2000 (Praxis Press) - The incidence of cancer increases after the diagnosis of venous thromboembolism, which is usually treated with vitamin K antagonists such as warfarin. Few randomized trials have examined the relation between the development of metastases and the clotting mechanism. During a prospective, randomized study that lasted eight years, Schulman and Lindmarker have compared the effects on the incidence of cancer of a six-week and a six-month warfarin treatment giv

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Gene targeting in sheep raises new hopes and fears

By | June 29, 2000

PPL Therapeutics Ltd of Roslin, Edinburgh, showed today how they succeeded a year ago (the delay was to secure a patent) in targeting a gene to a chosen location in embryonic sheep fibroblasts. Then they transferred the nucleus to stem cells and created whole transformed, gene-targeted sheep (Nature paper 1 and paper 2).We have succeeded in cloning sheep, goats, cows, pigs and mice, and now we have gene targeting in sheep. But it is proving difficult to clone whole animals efficiently, as the sc

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Amiodarone guidelines

June 28, 2000

New York, June 28, 2000 (Praxis Press) Clinical trials demonstrate the efficacy, broad anti-arrhythmic and anti-fibrillatory action, and complex array of adverse effects of amiodarone. The absence of general recommendations for proper patient management likely leads to both overuse and underuse of this drug. Practical guidelines from the North American Society of Pacing and Electrophysiology provide the physician with a consensus approach to the prescription of amiodarone (see paper). Based on t

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