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Depression and mortality

June 27, 2000

NEW YORK, June 27 (Praxis Press) Studies on whether depressive symptoms are associated with mortality in the elderly have yielded contradictory findings. To address these discrepancies, Schulz and colleagues studied a population-based sample of 5201 men and women aged 65 years and older (see paper). They examined depressive symptoms and four categories of covariates at baseline, with the primary outcome measure being mortality after six years. Of the 5201 participants, 984 (18.9%) died within 6

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Homocysteine and CAD

June 27, 2000

NEW YORK, June 27 (Praxis Press) Circulating homocysteine levels can be used to predict survival in patients with stable coronary artery disease. The prognostic value of serum homocysteine levels, obtained in the acute phase in patients with myocardial infarction or unstable angina, however, is unknown. To test this hypothesis, Omland and colleagues measured the serum homocysteine levels of a total of 579 patients with Q-wave myocardial infarction (n=163), non- Q-wave myocardial infarction (n=21

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How many human genes?

By | June 27, 2000

Between 38 000 and 115 000, say yesterday's press conferences on the human genome.

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Of mice and men

By | June 27, 2000

Does the mouse, biology's model mammal, mean the human genome race is still on?

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NEW YORK, June 27 (Praxis Press) Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit both cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) but it is unclear whether specific COX-2 inhibitors are as effective as NSAIDs in the treatment of osteoarthritis (OA). Day and colleagues compared the efficacy and safety of the rofecoxib, which specifically inhibits COX-2, with that of the NSAID ibuprofen in 809 adult patients with OA (see paper. They found that rofecoxib was as effective as ibuprofe

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Sigmoidoscopy discomfort

June 27, 2000

NEW YORK, June 27 (Praxis Press) Physicians often cite patient discomfort as a reason for not requesting screening flexible sigmoidoscopy. Patient experiences and attitudes toward sigmoidoscopy, however, have not been well studied. To measure patient satisfaction with screening sigmoidoscopy, Schoen and colleagues surveyed 1221 patients after sigmoidoscopy (see paper). They found that more than 93% of the participants strongly agreed or agreed they would be willing to undergo another examination

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Thrombosis treatment

June 27, 2000

NEW YORK, June 27 (Praxis Press) Heparins have been shown to be effective and safe in the treatment of deep vein thrombosis, but the use of this treatment on an outpatient versus an inpatient basis has not been compared. To compare the two treatment locales, Boccalon and colleagues conducted a randomized, comparative, multicenter trial and evaluated the clinical outcomes and treatment costs (see paper). The researchers examined 201 patients with proximal deep vein thrombosis and administered low

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Coloured cotton, a giant carp, Bt-resistant poplars - is anything holding Chinese biotechnology back? Yes, says Zhao Zhizen - a government that won't take any risks.

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Colposcopy guidelines

June 26, 2000

NEW YORK, June 26 (Praxis Press) Currently no guidelines exist for managing women with low grade cytological abnormalities, whose findings on colposcopy do not warrant immediate treatment. To develop an evidence-based protocol for these women, Teale and colleagues evaluated 566 women with low-grade cytological abnormalities who were not treated at a first visit to the colposcopy clinic, and followed them for a total of 881 years (see paper). Abnormalities resolved in 306 (54.1%) women, whereas 1

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NEW YORK, June 26 (Praxis Press) Type 2 diabetes mellitus is a common complication of iron-overload diseases such as hereditary hemochromatosis. Recently a gene mutation was identified that strongly predisposes individuals towards hemochromatosis when present in homozygous form. Salonen and colleagues examined whether a carrier status for the mutation predicts the development of type 2 diabetes (see paper). Out of a total of 555 participants, one was homozygous and 34 heterozygous for the HFE C2

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