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tag histones epigenetics histone methylation

Histone codes
Jonathan Weitzman(jonathanweitzman@hotmail.com) | Mar 18, 2001 | 1 min read
The histone code hypothesis posits that distinct combinations of histone modifications can recruit chromatin-modifying enzymes and exert epigenetic control over heterochromatin assembly. In the March 15 ScienceXpress, Nakayama et al. describe a role for histone methylation in heterochromatin assembly in the fission yeast Schizosaccharomyces pombe. The Clr4 protein methylated lysine 9 of histone H3 (H3Lys9) preferentially within heterochromatin-associated regions. H3Lys9 methylation led to the r
Heritable Histones
Ruth Williams | Sep 18, 2014 | 3 min read
Scientists show how roundworm daughter cells remember the histone modification patterns of their parents.
early-life stress, histone, chromatin, epigenetics, epigenetic modification, methylation, DNA, protein, stress, adversity, mice, genetics, genomics
Early-Life Stress Exerts Long-Lasting Effects Via Epigenome
Asher Jones | Mar 18, 2021 | 5 min read
In mice, epigenetic marks made on histones during infancy influence depression-like behavior during adulthood. A drug that reverses the genomic tags appears to undo the damage.
Histone Methylation is Making its Mark
Brendan Maher | Jan 26, 2003 | 6 min read
Data derived from the Science Watch/Hot Papers database and the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age. M. Lachner et al., "Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins," Nature, 410:116-20, 2001. (Cited in 202 papers) A.J. Bannister et al., "Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain," Nature, 410:120-4, 2001. (Cited in 2
Methylation mystery
Kelly Rae Chi | Oct 1, 2007 | 2 min read
David Allis from Rockefeller University and colleagues used a biochemical pull-down assay and found that the protein WDR5, a common part of histone methyltransferase complexes, associates specifically with dimethylated H3K4 nucleosomes.
Support for histone code?
Brendan Maher | May 21, 2006 | 2 min read
Four papers released online today detail some of the work from David Allis's group and others on chromatin remodeling. 
Illustration showing how yeast is used to study histone modifications
Infographic: A Yeast Model for Studying Histone Modifications
Amanda Heidt | Sep 1, 2021 | 1 min read
The methodology involves modifying histones and displaying them on the cell surface for analysis.
How epigenetics affects twins
Charles Choi(cqchoi@nasw.org) | Jul 6, 2005 | 3 min read
In genetically identical siblings, DNA methylation and histone acetylation correlate with age and lifestyle
Researchers Focus on Histone Code
Brendan Maher | Sep 16, 2001 | 4 min read
Histones, the proteins around which DNA coils to form chromatin, are moving toward the forefront of epigenetic research (see also, "The Meaning of Epigenetics"). A recently floated hypothesis states that the highly modifiable amino termini, or tails, of these proteins could carry their own combinatorial codes or signatures to help control phenotype, and that parts of this code may be heritable. Histones are perhaps more intimately linked with DNA than any other protein. Transcriptional regulati
Demystifying Histone Demethylases
Kerry Grens | Feb 1, 2008 | 4 min read
Identification of a demethylation protein domain brings on a flood of enzyme discoveries.

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