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The Nutshell

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Spark Therapeutics’s Luxturna would be the first approved therapy in the U.S. that replaces or repairs a defective gene inherited from one’s parents.

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image: Study Raises Questions About Patient-Derived Xenografts

Study Raises Questions About Patient-Derived Xenografts

By Ashley P. Taylor | October 10, 2017

When transplanted into mice, tumor genomes evolve differently than they do in patients, study finds.

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image: Gene Drive Limitations

Gene Drive Limitations

By Jef Akst | October 9, 2017

In lab populations of genetically engineered mosquitoes, mutations arose that blocked the gene drive’s spread and restored female fertility.

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Tissue recipients were treated as “guinea pigs,” says investigation leader.

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Researchers use base-editing to swap out an erroneous nucleotide responsible for a potentially life-threatening blood disorder.

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image: Canada Names Chief Science Advisor

Canada Names Chief Science Advisor

By Ashley P. Taylor | September 27, 2017

Scientists speculate about whether the appointment will mean more funding for research.

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image: Enormous University Gift Raises Questions over Donor Influence

Enormous University Gift Raises Questions over Donor Influence

By Ashley P. Taylor | September 26, 2017

The donation to the University of California, Irvine, is slated to fund a new college focusing on what some critics call pseudoscience and quackery.

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image: Facing Brexit, U.K. Makes Science Deal with U.S.

Facing Brexit, U.K. Makes Science Deal with U.S.

By Catherine Offord | September 22, 2017

The $88 million agreement is part of efforts by the UK government to increase transatlantic collaboration as the country prepares to leave the European Union.

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image: Most Accurate CRISPR Gene Editing Yet

Most Accurate CRISPR Gene Editing Yet

By Kerry Grens | September 22, 2017

A tweaked Cas9 nuclease reduces off-target effects to levels below that of previous versions of the enzyme.

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image: CRISPR Used in Human Embryos to Probe Gene Function

CRISPR Used in Human Embryos to Probe Gene Function

By Ashley P. Taylor | September 20, 2017

OCT4 is necessary for blastocyst formation in the human embryo, researchers report.

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