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image: Designing Transition-State Inhibitors

Designing Transition-State Inhibitors

By Vern L. Schramm | May 1, 2012

A transition-state mimic has the power to bind an enzyme at its tipping point as strongly as any available inhibitor and more strongly than most, preventing enzymatic activity. 

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image: Suspected Effects of Vitamin D

Suspected Effects of Vitamin D

By Amy Maxmen | March 1, 2012

Vitamin D has a variety of actions in the body. It binds to the vitamin D receptor (VDR), which then binds to the retinoid X receptor (RXR) and activates the expression of numerous genes. 

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image: The View From Above

The View From Above

By Cristina Luiggi | February 1, 2012

Satellite imagery is giving biologists a whole new perspective on the phenomena they study.

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image: Bat Hunt

Bat Hunt

By Cristina Luiggi | January 1, 2012

Bucknell University mammalogist DeeAnn Reeder raises nets high into the darkened forest canopies of South Sudan to catch bats.

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Saving Rwanda's Gorillas

By Jef Akst | October 1, 2011

In late June 2009, a small group of mountain gorillas in Rwanda’s Volcanoes National Park began to fall ill. One by one, 11 of the dozen apes started exhibiting severe respiratory problems. 

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image: Swallowing the Surgeon

Swallowing the Surgeon

By Erica Westly | October 1, 2011

In fewer than 15 years, nanomedicine has gone from fantasy to reality.

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image: The Right Sort

The Right Sort

By Richard P. Grant | August 1, 2011

Isolating specific cell types from a mass of plant or animal tissue is laborious and tricky. 

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image: Repainting Ancient Birds

Repainting Ancient Birds

By Megan Scudellari | July 1, 2011

Using synchrotron rapid scanning X-ray fluorescence to map the distribution of trace metals in avian fossils over 120 million-year-old, researchers reconstruct the pigment patterns of their feathers—revealing some of the extinct birds' long-lost colors.

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image: OPSINS: Tools of the trade

OPSINS: Tools of the trade

By Edward S. Boyden | July 1, 2011

The optogenetic toolset is composed of genetically encoded molecules that, when targeted to specific neurons in the brain, enable the electrical activity of those neurons to be driven or silenced by light. 

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image: Best in Academia, 2011

Best in Academia, 2011

By The Scientist Staff | July 1, 2011

Meet some of the finalists of this year's Best Places to Work in Academia survey. 

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