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techniques, genetics

Opinion: Should Human-Animal Chimeras Be Granted “Personhood”?
John D. Loike | May 23, 2018 | 4 min read
Determining which products of advanced biotechnology are deserving of legal protections is essential to our own social architecture.
CRISPR Patent Dispute Heard in Federal Court
Jim Daley | May 1, 2018 | 2 min read
In an ongoing legal battle, the University of California, Berkeley has challenged the Broad Institute’s patent claims on the gene editing technology.
Researchers Produce Alpaca Antibodies Using Yeast
Catherine Offord | Feb 13, 2018 | 2 min read
With multiple applications in biomedicine, the antibodies can now be made quickly, cheaply, and without the need for an alpaca or one of its relatives.
Top Technical Advances in 2017
Shawna Williams | Dec 24, 2017 | 3 min read
The year’s most impressive achievements include new methods to extend CRISPR editing, patch-clamp neurons hands-free, and analyze the contents of live cells.
CRISPR Proves Promising for Treating ALS in Mice
Katarina Zimmer | Dec 20, 2017 | 2 min read
The gene-editing tool was effective in disabling a defective gene responsible for some forms of amyotrophic lateral sclerosis. 
CRISPR Helps Mice Hear
Abby Olena, PhD | Dec 20, 2017 | 3 min read
Researchers reduce the severity of hereditary deafness in mice with the delivery of CRISPR-Cas9 protein-RNA complexes that inactivate a mutant gene in their inner ears. 
Infographic: Combo Method of Stem Cell Generation
Ruth Williams | Nov 30, 2017 | 1 min read
Simultaneous exposure to reprogramming and gene-editing plasmids efficiently produces edited pluripotent colonies.
Nonviral CRISPR Delivery a Success
Abby Olena, PhD | Oct 2, 2017 | 3 min read
Researchers use gold nanoparticles to deliver CRISPR-Cas9 and correct a point mutation in a mouse model of Duchenne muscular dystrophy. 
Designer DNA
Rachel Berkowitz | Oct 1, 2017 | 7 min read
Computational tools for mapping out synthetic nucleic acids
Custom-Made Molecules
Ruth Williams | Aug 20, 2017 | 3 min read
A new prototype machine can make the biological molecules of one’s choice from digital DNA sequences.
Was a Drop in CRISPR Firms’ Stock Warranted?
Claire Asher | Jun 7, 2017 | 4 min read
A study of off-target effects that sparked fear among investors of genome-editing companies receives methodological criticisms.
Synthetic Stem Cells Regenerate Heart Tissue in Mice
Diana Kwon | Jun 1, 2017 | 2 min read
These engineered “cells” were made from the secretions and membranes of human mesenchymal stem cells.
Massively Parallel Perturbations
Ruth Williams | Mar 1, 2017 | 2 min read
Scientists combine CRISPR gene editing with single-cell sequencing for genotype-phenotype screens.
Infographic: Single-Cell CRISPR Screens
Ruth Williams | Feb 28, 2017 | 1 min read
See how two new methods track responses to unique genetic manipulations in numerous individual cells in parallel.
Broad Wins CRISPR Patent Interference Case
Jef Akst | Feb 15, 2017 | 3 min read
The USPTO’s Patent Trial and Appeal Board has ruled in favor of the Broad Institute of MIT and Harvard retaining intellectual property rights covered by its patents for CRISPR gene-editing technology.
Top Technical Advances 2016
Kerry Grens | Dec 15, 2016 | 4 min read
The year’s most impressive achievements include methods to watch translation in cells, trace cell fates, avoid mitochondrial mutations, edit DNA, and build antibiotics from scratch.
Gene Editing: From Roots to Riches
Amanda B. Keener | Oct 1, 2016 | 5 min read
Advances in genetic manipulation have simplified the once daunting task of rewriting a gene.
DNA Sequencing: From Tedious to Automatic
Catherine Offord | Oct 1, 2016 | 5 min read
Sequencing has gone from a laborious manual task costing thousands of dollars to a quick and cheap practice that is standard for many laboratories.
Toggling CRISPR Activity with a Chemical Switch
Kerry Grens | Sep 12, 2016 | 1 min read
Researchers design a Cas9 enzyme that cuts DNA only in the presence of particular drug.
That Other CRISPR Patent Dispute
Kerry Grens | Aug 31, 2016 | 5 min read
The Broad Institute and Rockefeller University disagree over which scientists should be named as inventors on certain patents involving the gene-editing technology.
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