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image: Anatomy of C. Difficile

Anatomy of C. Difficile

By | June 2, 2011

Clostridium difficile is a spore-forming, gram-positive bacterium that can cause disease when ingested. 


image: Tibetan medical paintings

Tibetan medical paintings

By | May 15, 2011

Seventeenth-century Tibet witnessed a blossoming of medical knowledge, with the construction of a monastic medical college and the penning of several influential medical texts. Perhaps most striking was a set of 79 paintings, known as tangkas, which


image: Micro Farmers

Micro Farmers

By | May 1, 2011

Columbia University evolutionary ecologist Dustin Rubenstein explains just why it's so interesting and important to find slime molds that engage in a form of agriculture.


image: Taking Aim at Melanoma

Taking Aim at Melanoma

By | April 1, 2011

Antigen-presenting cells, such as macrophages or dendritic cells, elicit an immune response by displaying tumor antigens bound to the major histocompatibility complex (MHC) to circulating T-cells. Simultaneous T-cell recognition of glycoproteins CD80


image: Molecular Targeting of BRAF Mutations

Molecular Targeting of BRAF Mutations

By | April 1, 2011

BRAF is the most commonly mutated gene associated with melanoma, found in more than 50 percent of patients. The gene encodes a cytoplasmic kinase that is a member of the MAPK signal-transduction pathway, which is activated when growth factors bind to


image: Vital Signs

Vital Signs

By | April 1, 2011

Radiology scientist Alexander Lin talks about searching for the tell-tale biomarkers of chronic traumatic encephalopathy.  


image: Optical Tweezers

Optical Tweezers

By | April 1, 2011

Institut Curie researchers Bruno Goud, a biologist, and Patricia Bassereau, a physicist, talk about their fruitful, decade-long collaboration exploring the physics of membrane trafficking in a Skype interview conducted by Associate Editor Richard P. Grant.


image: Where Cancer and Inflammation Intersect

Where Cancer and Inflammation Intersect

By | April 1, 2011

Recent clinical trials have reignited the interest in simple anti-inflammatory drugs like aspirin for controlling the inflammation associated with cancer. 


image: Epigenetic Changes in Cancer

Epigenetic Changes in Cancer

By | March 1, 2011

In cancer cells the epigenetic landscape is highly altered. Hypermethylation of certain stretches of DNA is the most well-studied epigenetic modification in cancer, and each tumor type has its own specific pattern. Histone modifications also occur, a


image: Epigenetics—A Primer

Epigenetics—A Primer

By | March 1, 2011

Epigenetic events regulate the activities of genes without changing the DNA sequence. Different genes are expressed depending on the methyl-marks attached to DNA itself and by changes in the structure and/or composition of chromatin. 


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