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image: Macrophages Play a Double Role in Cancer

Macrophages Play a Double Role in Cancer

By Amanda B. Keener | April 1, 2018

Macrophages play numerous roles within tumors, leaving cancer researchers with a choice: eliminate the cells or recruit them.

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The neuronal coverings that mediate synaptic changes are involved in everything from memory to psychiatric disorders, affecting autism, Alzheimer’s, and addiction.

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Multidrug combinations lead to better results for cancer patients, but efficiently identifying them is proving difficult.

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Research into the biological basis of gender identity is in its infancy, but clues are beginning to emerge.

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image: Glial Ties to Persistent Pain

Glial Ties to Persistent Pain

By Mark R. Hutchinson | January 1, 2018

Immune-like cells in the central nervous system are now recognized as key participants in the creation and maintenance of persistent pain.

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image: Targeting Sodium Channels for Pain Relief

Targeting Sodium Channels for Pain Relief

By Catherine Offord | January 1, 2018

The race to develop analgesic drugs that inhibit sodium channel NaV1.7 is revealing a complex sensory role for the protein.

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image: Frog Skin Yields Potent Painkillers, but None Clinic Ready

Frog Skin Yields Potent Painkillers, but None Clinic Ready

By Shawna Williams | January 1, 2018

Decades after their discovery by bioprospectors, amphibian-derived analgesics continue to attract scientific attention.

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image: Mining Spider Toxins for Analgesic Clues

Mining Spider Toxins for Analgesic Clues

By Catherine Offord | January 1, 2018

Arachnids harbor a plentiful array of molecules that target mammalian pain receptors.

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image: Novel Analgesics at a Snail’s Pace

Novel Analgesics at a Snail’s Pace

By Bob Grant | January 1, 2018

Studying cone snail venom has yielded novel pain pathways, but the peptides that function as toxins are difficult to translate into drugs.

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image: Researchers Mine Centipede Toxins for Analgesics

Researchers Mine Centipede Toxins for Analgesics

By Catherine Offord | January 1, 2018

Venomous centipedes may harbor a clue to the creation of a successful pain-killing compound for humans.

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