cancer, immunology

Mice treated with an immunostimulant had better outcomes when researchers blocked the expression of TNFR2, a compound that helps tumors evade immune attack.

In the presence of cytosolic DNA, cancer cells activate antiviral pathways that disguise them as immune cells.

Errors in segregation during cell division can lead to inflammation in daughter cells.

Stem cells and cancer cells have enough molecular similarities that the former can be used to trigger immunity against the latter.

US researchers could become the first outside China to use the gene-editing technique in the clinic. 

A team has engineered two stem cell lines into “synthetic T cells” that destroy breast cancer cells in vitro. 

The therapy, produced by Kite Pharma and owned by Gilead Sciences, is approved for use against some types of large B-cell lymphomas. 

In mice, the tumor cells are able to thwart the immune response that would kill them—but immunotherapy prevented the return of melanoma.

In addition to circulating in the blood as immune sentinels, macrophages play specialized roles in different organs around the body.

Identifying immune cell subsets with CyTOF

Mounting evidence suggests that intermittent fasting causes significant changes to various organs and tissue types.

Following a spate of patient deaths in clinical trials testing modified T cells for the treatment of cancer, researchers work to reduce the treatment’s toxicity without sacrificing efficacy.

Tumors’ mutations can encode the seeds of their own destruction, in the form of immunogenic peptides recognized by T cells.

New monoclonal antibodies kill both cancer-promoting immunosuppressive cells and tumor cells in culture.