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When the O’Neills learned that their daughter had Sanfilippo syndrome, a devastating rare disease, they created a GoFundMe campaign that raised $2 million in less than a year.

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Crowdfunding can power investigations into diseases that would otherwise receive little attention.

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image: Slow March Toward a Canavan Cure

Slow March Toward a Canavan Cure

By Ashley Yeager | May 1, 2018

Two decades after a successful crowdfunding campaign, some clinical trial patients have seen improvements—but there’s still no approved treatment for the disease.

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Though Calliope Joy’s disease is too far progressed to be treatable, her parents have helped other children with metachromatic leukodystrophy get access to an experimental therapy.

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image: Macrophages Play a Double Role in Cancer

Macrophages Play a Double Role in Cancer

By Amanda B. Keener | April 1, 2018

Macrophages play numerous roles within tumors, leaving cancer researchers with a choice: eliminate the cells or recruit them.

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Multidrug combinations lead to better results for cancer patients, but efficiently identifying them is proving difficult.

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image: Targeting Sodium Channels for Pain Relief

Targeting Sodium Channels for Pain Relief

By Catherine Offord | January 1, 2018

The race to develop analgesic drugs that inhibit sodium channel NaV1.7 is revealing a complex sensory role for the protein.

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image: 2017 Life Science Salary Survey

2017 Life Science Salary Survey

By Aggie Mika | November 1, 2017

Industry professionals make more than academic researchers, but for professors, it may not be about the money.

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image: Getting Drugs Past the Blood-Brain Barrier

Getting Drugs Past the Blood-Brain Barrier

By Amanda B. Keener | November 1, 2017

To treat neurological disease, researchers develop techniques to bypass or trick the guardian of the central nervous system.

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image: Do Pathogens Gain Virulence as Hosts Become More Resistant?

Do Pathogens Gain Virulence as Hosts Become More Resistant?

By Andrew F. Read and Peter J. Kerr | October 1, 2017

Emerging infections provide clues about how pathogens might evolve when farm animals are protected from infection.

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