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image: Macrophages Play a Double Role in Cancer

Macrophages Play a Double Role in Cancer

By Amanda B. Keener | April 1, 2018

Macrophages play numerous roles within tumors, leaving cancer researchers with a choice: eliminate the cells or recruit them.

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Multidrug combinations lead to better results for cancer patients, but efficiently identifying them is proving difficult.

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image: How Cancers Evolve Drug Resistance

How Cancers Evolve Drug Resistance

By Anna Azvolinsky | April 1, 2017

Researchers unravel the sophisticated ways cancers evade treatments, including immunotherapies, designed to destroy them.

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image: Neoantigens Enable Personalized Cancer Immunotherapy

Neoantigens Enable Personalized Cancer Immunotherapy

By Stephen P. Schoenberger and Ezra Cohen | April 1, 2017

Tumors’ mutations can encode the seeds of their own destruction, in the form of immunogenic peptides recognized by T cells.

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image: May the Force Be with You

May the Force Be with You

By Ning Wang | February 1, 2017

The dissection of how cells sense and propagate physical forces is leading to exciting new tools and discoveries in mechanobiology and mechanomedicine.

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image: Repurposing Existing Drugs for New Indications

Repurposing Existing Drugs for New Indications

By Anna Azvolinsky | January 1, 2017

An entire industry has sprung up around resurrecting failed drugs and recycling existing compounds for novel indications.

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image: Toward Targeted Therapies for Autoimmune Disorders

Toward Targeted Therapies for Autoimmune Disorders

By Lawrence Steinman | June 1, 2016

Training the immune system to cease fire on native tissues could improve outcomes for autoimmune patients, but clinical progress has been slow.

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image: A Different Way of Doing Things

A Different Way of Doing Things

By Kivanç Birsoy and David M. Sabatini | April 1, 2016

Cancer cells exhibit altered metabolic processes that may serve as promising targets for new therapies.

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image: Microbes Meet Cancer

Microbes Meet Cancer

By Kate Yandell | April 1, 2016

Understanding cancer’s relationship with the human microbiome could transform immune-modulating therapies.

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image: The Forces of Cancer

The Forces of Cancer

By Lance L. Munn and Rakesh K. Jain | April 1, 2016

A tumor’s physical environment fuels its growth and causes treatment resistance.

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