ADVERTISEMENT
ADVERTISEMENT

drug development, disease & medicine

novartis avexis zolgensma gene therapy fda manipulated data
Leaders of AveXis Out Over Doctored Gene Therapy Data
Kerry Grens | Aug 14, 2019 | 1 min read
Novartis, which bought the biotech firm in 2018, announced that the company’s top scientists have left, and news reports say it’s because they were involved in using manipulated data to get the gene therapy Zolgensma approved.
Microneedle patch delivers liquid medications
Image of the Day: Artificial Snake Bite
Nicoletta Lanese | Aug 6, 2019 | 1 min read
A microneedle delivers liquid medicines through tiny, fang-like points.
Researchers Launch First Study of In Vivo CRISPR Therapy in Humans
Catherine Offord | Jul 26, 2019 | 1 min read
A trial is recruiting patients to test the gene-editing technology’s ability to treat an inherited form of blindness caused by a mutation in the CEP290 gene.
microbiome drugs
How the Microbiome Influences Drug Action
Shawna Williams | Jul 15, 2019 | 10+ min read
Through their effects on metabolism and immunity, bacteria in the gut affect whether medications will be effective for a given patient.
telomere length sticky stuck chromosome aging apoptosis cancer cell oxidative stress
Image of the Day: Sticky Telomeres
Chia-Yi Hou | May 16, 2019 | 1 min read
Telomeres in cancer cells exposed to oxidative stress got shorter and stickier.
Autism Symptoms May Improve with Modification of Hormone Pathway
Catherine Offord | May 2, 2019 | 2 min read
Two clinical trials that altered vasopressin signaling report improved social functions in people with autism spectrum disorder, but researchers caution against overinterpreting the results.
computing a cure
Artificial Intelligence Shakes Up Drug Discovery
Bianca Nogrady | May 1, 2019 | 8 min read
The pharmaceutical industry is looking to machine learning to overcome complex challenges in drug development.
Donor-Derived iPS Cells Show Promise for Treating Eye Disease
Jef Akst | Apr 30, 2019 | 2 min read
Age-related macular degeneration patients who received injections of retinal cells derived from donors’ induced pluripotent stem cells have maintained their level of eyesight for a year.
nancy davidson fred hutch epigenetics breast cancer
Q&A: Epigenetic Therapies for Breast Cancer
Katarina Zimmer | Apr 4, 2019 | 4 min read
Breast cancer researcher and oncologist Nancy Davidson discusses what we’ve learned from the first wave of epigenetic trials for breast cancer, and what challenges lie ahead before such therapies reach the clinic.
measles
In Three Months, US Measles Cases Surpass 2018 Numbers
Carolyn Wilke | Apr 2, 2019 | 2 min read
Most people who contracted the disease were unvaccinated and some state legislatures are now considering whether to curtail nonmedical vaccine exemptions.
small-molecule therapeutics treat cancer and other diseases
Scientists Take Aim at Disease-Causing RNAs Using Small-Molecule Drugs
Claire Asher | Apr 1, 2019 | 9 min read
Renewed interest from the biotech industry sparks hope for drugging the nucleic acid to treat cancer and other conditions.
april 2019 editorial the scientist
Miracle Elixirs
Bob Grant | Apr 1, 2019 | 3 min read
A long way into the quest to vanquish cancer, our ears strain to hear the words, “Cancer is cured”—a yearning that can cloud our judgment.
Image of the Day: Wiggles and Squirms
Carolyn Wilke | Mar 29, 2019 | 1 min read
An artificially intelligent program tracks the motion of infants to help doctors look for links to disorders with abnormal motions.
anesthesia 2019 march editorial
Drugs, Developed
Bob Grant | Mar 1, 2019 | 3 min read
In an era of instant communication, we must be careful how word of new and untested treatments is shared.
Emily Derbyshire scientist to watch
Emily Derbyshire Looks for Malaria’s Vulnerabilities
Shawna Williams | Mar 1, 2019 | 3 min read
The Duke University professor studies the parasite to find a way to thwart infection before it takes hold.
malaria feature
Are We Headed for a New Era of Malaria Drug Resistance?
Natalie Slivinski | Mar 1, 2019 | 10+ min read
Plasmodium falciparum has shown an ability to evade everything we throw at it, most recently artemisinin-based combination therapies, today’s front-line treatment.
Boosting Plants’ Uptake of Vitamins and Minerals
Ashley Yeager | Feb 1, 2019 | 4 min read
With genetic tweaks, researchers can coax corn and other cereals to take in more iron, but sometimes the plants rebel.
Parkinson’s Patient Transplanted with Neurons Derived from iPSCs
Ashley P. Taylor | Nov 14, 2018 | 2 min read
This is the first time researchers have tested the use of the reprogrammed stem cells in the human brain.
Ebola Clinical Trial to Begin Amid Outbreak in DRC
Ashley P. Taylor | Nov 12, 2018 | 2 min read
The study will examine the efficacy of four drugs—an antiviral and three monoclonal antibodies—that are already being used to treat patients in Democratic Republic of Congo.
Drug Cocktail Slows Progress of Aggressive Breast Cancer
Ashley P. Taylor | Oct 22, 2018 | 2 min read
Checkpoint inhibition combined with chemotherapy gives patients with triple-negative metastatic breast cancer about two months more time without significant tumor growth, a study finds.
ADVERTISEMENT