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Cross-Resistance: One Cancer Therapy Can Undermine the Next
Targeted cancer therapy may jeopardize the effectiveness of subsequent immunotherapy by reducing dendritic cell numbers and activation, according to study of mice and patient samples.
Cross-Resistance: One Cancer Therapy Can Undermine the Next
Cross-Resistance: One Cancer Therapy Can Undermine the Next

Targeted cancer therapy may jeopardize the effectiveness of subsequent immunotherapy by reducing dendritic cell numbers and activation, according to study of mice and patient samples.

Targeted cancer therapy may jeopardize the effectiveness of subsequent immunotherapy by reducing dendritic cell numbers and activation, according to study of mice and patient samples.

cell & molecular biology, immunology, cancer

Contributors
Asher Jones and Kerry Grens | Apr 1, 2021 | 3 min read
Meet some of the people featured in the April 2021 issue of The Scientist.
“Rogue” Protein Could Contribute to Humans’ High Cancer Rates
Asher Jones | Apr 1, 2021 | 2 min read
A mutant protein called Siglec-XII may promote carcinoma progression in humans, but inactivation of its gene seems to avoid the problem, according to a study.
Bisrat Debeb Models How Cancer Spreads to the Brain
Catherine Offord | Apr 1, 2021 | 3 min read
From his student days in veterinary medicine in Ethiopia to running a lab on metastasis at MD Anderson Cancer Center, Debeb has a passion for understanding how living things work.
Investigating the Immune Response Using Advanced Flow Cytometry
The Scientist | Oct 8, 2020 | 1 min read
Discover how researchers are using flow cytometry to delve into the inner workings of the immune life cycle!
Natural Killer Cells Prove Effective as a CAR Therapy in Mice
Katarina Zimmer | Jul 6, 2018 | 4 min read
Stem-cell–derived natural killer cells engineered in a similar way to CAR-T cells may pave the way to “off the shelf” cancer therapies that aren’t patient-specific.
A T-Cell Tweak Combats Advanced Breast Cancer
Ashley Yeager | Jun 5, 2018 | 2 min read
The immunotherapy eliminated a woman’s metastatic lesions and kept her disease-free for two years.
Stem Cell Vaccine Protects Mice From Cancer
Ruth Williams | Feb 15, 2018 | 3 min read
Stem cells and cancer cells have enough molecular similarities that the former can be used to trigger immunity against the latter.
Infographic: Macrophages Around the Body
Claire Asher | Sep 30, 2017 | 2 min read
In addition to circulating in the blood as immune sentinels, macrophages play specialized roles in different organs around the body.
Week in Review: October 17–21
Jef Akst | Oct 20, 2016 | 2 min read
Report finds that pathologist involved in anonymous defamation case committed multiple acts of misconduct; growing eggs from stem cells; neutrophils’ role in metastasis; convergent evolution in birds
Tumor Traps
Kerry Grens | Apr 1, 2016 | 2 min read
After surgery to remove a tumor, neutrophils recruited to the site spit out sticky webs of DNA that aid cancer recurrence.
Mutations Not Tied to Metastasis
Kerry Grens | Feb 25, 2016 | 3 min read
Clinical cases link immune changes to a cancer’s spread through the body, but find no role for so-called “driver” mutations.
Cancer Immunotherapist
Jef Akst | Mar 31, 2015 | 1 min read
Scientist to Watch Yvonne Saenger explains recent advances in using biomarkers to identify cancer patients who might benefit most from immunotherapy.
A Cancer Culprit in Autoimmunity
Ruth Williams | Dec 5, 2013 | 3 min read
Scientists discover that cancer can drive the autoimmune disorder scleroderma.
Where Cancer and Inflammation Intersect
Giorgio Trinchieri | Apr 1, 2011 | 1 min read
Recent clinical trials have reignited the interest in simple anti-inflammatory drugs like aspirin for controlling the inflammation associated with cancer. 
An Aspirin for your Cancer?
Giorgio Trinchieri | Apr 1, 2011 | 10+ min read
Can tumors—which can originate from, and often resemble, chronically inflamed tissue—be curtailed using familiar anti-inflammatory agents, without their side effects?
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