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tag mutations dna methylation bone growth disease medicine

Image of the tissue surrounding a pancreatic tumor thickening and scarring.
How Pancreas Injuries Can Cause Cancer in Mice
Dan Robitzski | Nov 9, 2021 | 4 min read
A key mutation turns healing cells into cancer promoters.
bacteria and DNA molecules on a purple background.
Engineering the Microbiome: CRISPR Leads the Way
Mariella Bodemeier Loayza Careaga, PhD | Mar 15, 2024 | 10+ min read
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.
Composite image showing genes radiating from tumor cells
Jumping Genes’ Role in Cancer
Diana Kwon | Mar 1, 2023 | 8 min read
Transposons may be key players in how tumors develop and spread, but they also keep cancer at bay in some circumstances.
Rare Disease Geneticist: A Profile of Uta Francke
Anna Azvolinsky | May 1, 2018 | 9 min read
The Stanford University human geneticist identified the genes and genomic abnormalities underlying numerous rare diseases, including Rett  syndrome, and advanced the field of molecular diagnostics. 
Methylation: Gene Expression at the Right Place and Right Time
Nadia Halim | Dec 5, 1999 | 7 min read
Courtesy of Richard Roberts, New England BiolabsModel methylation reaction: Cytosine nucleotide (red) is flipped out of the DNA double helix by a methyltransferase (white), so it can be methylated. The end product after the methyl group has been transferred to the DNA is pictured in green. A tenuous link between DNA methylation and development has existed for several years. Now findings substantiate the connection. Researchers have found the first human diseases caused by defects in the DNA meth
Aging and Cancer
Aging and Cancer
Rebecca Roberts, PhD | Nov 14, 2023 | 6 min read
The relationship between aging and cancer is complex, with several shared underlying mechanisms. 
3d rendered medically accurate illustration of a human embryo anatomy
The Ephemeral Life of the Placenta
Danielle Gerhard, PhD | Dec 4, 2023 | 10+ min read
Recent advances in modeling the human placenta, the least understood organ, may inform placental disorders like preeclampsia.
First, Do No Harmā€¦
Jim Woodgett | Jun 9, 2011 | 5 min read
Is DNA damage an inevitable consequence of epigenetic reprogramming?
Telomeres in Disease
Rodrigo Calado and Neal Young | May 1, 2012 | 10+ min read
Telomeres have been linked to numerous diseases over the years, but how exactly short telomeres cause diseases and how medicine can prevent telomere erosion are still up for debate.
Research Notes
Nadia Halim | Feb 20, 2000 | 6 min read
Methylation as a Cancer Switch Courtesy of Richard Roberts, New England BiolabsReaction model: Methyltransferase (white) is methylating cyclic carbon 5 of a cytosine nucleotide. The tenuous link between cancer and epigenetic changes, changes in gene expression without DNA mutations, has been strengthened by Joe Costello, assistant professor at the University of California, San Francisco, and colleagues (J.F. Costello et al., "Aberrant CpG-island methylation has non-random and tumour-type-specifi

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