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tag mutations dna methylation stem cells techniques human evolution

A Long Line of LINEs
Kate Yandell | Sep 1, 2014 | 3 min read
Different mechanisms repress mobile DNA elements in human embryonic stem cells depending on the elements’ evolutionary ages.
a trio of infant mice, two brown mice on the ends and one white mouse in the middle
Mice Pass Epigenetic Tweaks to Pups
Katherine Irving | Feb 17, 2023 | 5 min read
An engineered methylation pattern persisted for four generations of mice, demonstrating transgenerational epigenetic inheritance can occur in mammals.
New Techniques Detail Embryos’ First Hours and Days
Jef Akst | Dec 1, 2017 | 10+ min read
New technologies reveal the dynamic changes in mouse and human embryos during the first week after fertilization.
A close-up image of pale green seeds inside of a green capsule taken by a scanning electron microscope
Essential Genes Protected from Mutations
Dan Robitzski | Jan 25, 2022 | 6 min read
Epigenetic structures appear to reduce the rate of changes in genes essential for survival and reproduction, a study finds, challenging the notion that mutations are evenly distributed throughout the genome prior to selection.
First, Do No Harm…
Jim Woodgett | Jun 9, 2011 | 5 min read
Is DNA damage an inevitable consequence of epigenetic reprogramming?
The Role of DNA Base Modifications
Skirmantas Kriaucionis | Sep 1, 2017 | 10+ min read
Researchers are just beginning to scratch the surface of how several newly recognized epigenetic changes function in the genome.
zebrafish in an aquarium
Epigenetics May Remember Ancestors’ Mutations
Holly Barker, PhD | Dec 1, 2022 | 4 min read
Parents’ mutations, even if they’re not inherited by offspring, could affect subsequent generations through changes to epigenetic marks, a study finds.
3d rendered medically accurate illustration of a human embryo anatomy
The Ephemeral Life of the Placenta
Danielle Gerhard, PhD | Dec 4, 2023 | 10+ min read
Recent advances in modeling the human placenta, the least understood organ, may inform placental disorders like preeclampsia.
On the left is a normally developing mouse embryo, on the right is a slightly larger mouse embryo that also contains horse cells that glow green.
Chimera research opens new doors to understanding and treating disease
Hannah Thomasy, PhD, Drug Discovery News | Aug 9, 2023 | 10 min read
Animals with human cells could provide donor organs or help us understand neuropsychiatric disorders.
Top Technical Advances 2016
Kerry Grens | Dec 15, 2016 | 4 min read
The year’s most impressive achievements include methods to watch translation in cells, trace cell fates, avoid mitochondrial mutations, edit DNA, and build antibiotics from scratch.

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