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tag mutations techniques limb development human evolution

A close up of a tick held in a pair of forceps, with Kevin Esvelt’s face out of focus in the background.
CRISPR Gene Drives and the Future of Evolution
Hannah Thomasy, PhD | Mar 15, 2024 | 10+ min read
Genetic engineering pioneer Kevin Esvelt’s work highlights biotechnology’s immense potential for good—but also for catastrophe.
A Simple Genetic Change Adds Limb-Like Bones to Zebrafish Fins
Abby Olena, PhD | Feb 5, 2021 | 4 min read
A gain-of-function mutation in a single gene reveals ancient limb-forming capacity that has been preserved for hundreds of millions of years.
Composite image of earliest humans and wooly mammoths
New Evidence Complicates the Story of the Peopling of the Americas
Emma Yasinski | May 2, 2022 | 10+ min read
New techniques have shown that people reached the New World far earlier than the long-standing estimate of 13,000 years ago, but scientists still debate exactly when humans arrived on the continent—and how.
The illustration shows floating chromosomes with a Y-shaped chromosome in the foreground.
Closing the Gaps in the Human Genome: Why Y Was the Final Hurdle
Kamal Nahas, PhD | Aug 28, 2023 | 4 min read
For two decades, scientists struggled to fully sequence the Y chromosome. Finally, researchers have mapped its full length thanks to recent advances in sequencing technology.
Animalsā€™ Embryonic Organizer Now Discovered in Human Cells
Jim Daley | May 23, 2018 | 4 min read
The finding confirms that a cluster of cells that directs the fate of other cells in the developing embryo is evolutionarily conserved across the animal kingdom.
Green-tinged image of fly eye with shiny and black portions
New CRISPR Technique Causes Few Unintended Mutations in Fruit Flies
Jason P. Dinh | Jul 1, 2022 | 4 min read
A study finds that CRISPR-Nickase, which changes just one allele of a given gene, improves gene editing efficiency compared with CRISPR-Cas9.
A close-up image of pale green seeds inside of a green capsule taken by a scanning electron microscope
Essential Genes Protected from Mutations
Dan Robitzski | Jan 25, 2022 | 6 min read
Epigenetic structures appear to reduce the rate of changes in genes essential for survival and reproduction, a study finds, challenging the notion that mutations are evenly distributed throughout the genome prior to selection.
bacteria and DNA molecules on a purple background.
Engineering the Microbiome: CRISPR Leads the Way
Mariella Bodemeier Loayza Careaga, PhD | Mar 15, 2024 | 10+ min read
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.
Infusion of Artificial Intelligence in Biology
Meenakshi Prabhune, PhD | Feb 23, 2024 | 10 min read
With deep learning methods revolutionizing life sciences, researchers bet on de novo proteins and cell mapping models to deliver customized precision medicines.
New Methods to Detect CRISPR Off-Target Mutations
Sandeep Ravindran | Mar 1, 2018 | 7 min read
Researchers have developed a variety of techniques to detect when CRISPR misses the mark.

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